Environmental and occupational exposure to bisphenol A and endometriosis: urinary and peritoneal fluid concentration levels
Environmental and occupational exposure to bisphenol A and endometriosis: urinary and peritoneal fluid concentration levels
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DOI：
10.1007/s00420-016-1171-1
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发表时间：
2016
影响因子：
3
通讯作者：
A. Simonelli;R. Guadagni;P. De Franciscis;N. Colacurci;M. Pieri;P. Basilicata;P. Pedata;M. Lamberti;N. Sannolo;N. Miraglia
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文献类型：
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作者：
A. Simonelli;R. Guadagni;P. De Franciscis;N. Colacurci;M. Pieri;P. Basilicata;P. Pedata;M. Lamberti;N. Sannolo;N. Miraglia
ObjectivesThe study aims to give a first data set of bisphenol A（BPA）levels in the peritoneal fluid of patients suffering from endometriosis and to investigate the relationship between BPA exposure and endometriosis.MethodsA questionnaire investigating the occupational context，life environment，and habits was administered to 68 patients suffering from endometriosis and 60 patients-free subjects（control group）.尿液和腹腔液样本收集和分析的GC/MSMS BPA dose.Resultssome的调查环境/生活方式的风险因素（接近行业/活动的风险）与子宫内膜异位症的增加;吸烟导致的保护因素;其他（使用食品塑料盒）似乎没有影响发病的病理。子宫内膜异位症与职业暴露（包括工作活动、个人防护用品、工龄）的相关性有统计学意义（χ2= 5.252，p = 0.02）。当检查具体活动时，得到了相反的结果。在所有分析的样本中发现了可检测的尿BPA水平（患者：1.17-12.68 pg/µl;平均值±标准差，5.31 ± 3.36 pg/µl;对照组：1.28-2.35 pg/µl;平均值±标准差，1.64 ± 0.49 pg/µl;中位数; 1.46 pg/µl），患者和对照组之间存在统计学显著差异，表明BPA暴露与子宫内膜异位症之间存在关联。对照组中只有少数受试者提供腹膜液;因此，没有与患者进行比较试验（范围0.39-1.46 pg/µl;平均值± SD，0.67 ± 0.30 pg/µl;中位数为0.58 pg/µl）。结论结果强调了BPA暴露与子宫内膜异位症之间的潜在关联，以及目前缺乏关于职业暴露于BPA的知识，以及需要对单一活动/职业进行流行病学研究，如家庭主妇、清洁工、学生。
ObjectivesThe study aimed to give a first data set of bisphenol A (BPA) levels in the peritoneal fluid of patients suffering from endometriosis and to investigate the relationship between BPA exposure and endometriosis.MethodsA questionnaire investigating the occupational context, life environment, and habits was administered to 68 patients suffering from endometriosis and 60 endometriosis-free subjects (control group). Urine and peritoneal fluids samples were collected and analysed by GC/MSMS for BPA dosage.ResultsSome of the investigated environmental/lifestyle risk factors (closeness to industries/activities at risk) were associated with an increase in endometriosis; smoking resulted as protective factor; others (use of food plastic boxes) did not seem to influence the onset of pathology. The association between the occupational exposure summarising all examined risk factors (working activity, personal protective equipment, seniority) and endometriosis was statistically significant (χ2= 5.252,p= 0.02). Contrasting results were obtained when specific activities were examined. Detectable urinary BPA levels were found in all analysed samples (patients: 1.17–12.68 pg/µl; mean ± SD, 5.31 ± 3.36 pg/µl; control group: 1.28–2.35 pg/µl; mean ± SD, 1.64 ± 0.49 pg/µl; median; 1.46 pg/µl), with a statistically significant difference between patients and controls, showing an association between BPA exposure and endometriosis. Only a few subjects from the control group supplied peritoneal fluid; hence, no comparison test with patients (range 0.39–1.46 pg/µl; mean ± SD, 0.67 ± 0.30 pg/µl; median, 0.58 pg/µl) was carried out.ConclusionsResults highlight the potential association between BPA exposure and endometriosis, as well as the current lack of knowledge regarding occupational exposure to BPA and the need of epidemiological studies focused on single activities/occupations, such as housewives, cleaners, students.