RBE of ion beams in hypofractionated radiotherapy (SBRT)
RBE of ion beams in hypofractionated radiotherapy (SBRT)
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DOI：
10.1016/j.ejmp.2014.04.009
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发表时间：
2014-07-01
影响因子：
3.4
通讯作者：
Scholz, Michael
中科院分区：
文献类型：
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作者：
Friedrich, Thomas;Scholz, Uwe;Scholz, Michael
与传统的光子辐射相比，碳离子束在肿瘤治疗中的一个重要优势是其相对生物有效性（RBE）的提高。由于RBE除其他因素外取决于剂量水平，因此准确了解RBE与剂量的关系对于比较涉及每组分不同剂量的不同分馏方案尤为重要。在这里，我们描述了RBE与剂量依赖关系的一些一般特性，这些特性是使用基于线性二次模型的简单建模方法以及用于描述RBE的更复杂的预测模型来确定的。我们表明，对于这两种方法，RBE对细胞或组织类型的系统依赖（以光子线性二次参数的α / β比值为特征）预计在高剂量下与低剂量相比是相反的。我们证明了这种反演不是模型特有的特征，而是由剂量响应曲线的线性二次曲线形状和RBE与光子α / β比之间的相关性引起的一个相当普遍的特征。研究结果讨论了其他建模方法及其对临床应用碳离子束使用低分割治疗方案的影响。(C) 2014年意大利医药工业协会。Elsevier Ltd.出版。版权所有。
An important advantage for the application of carbon ion beams in tumour therapy is their increased relative biological effectiveness (RBE) as compared to conventional photon radiation. Since RBE among other factors depends on the dose level, the precise knowledge of the RBE dependence on the dose is of particular importance for the comparison of different fractionation schemes, involving different doses per fraction. Here we describe some general properties of the RBE vs. dose dependence, which are determined using a simple modelling approach based on the linear-quadratic model as well as a more sophisticated predictive model for the description of RBE. We show that for both approaches the systematic dependence of RBE on the cell or tissue type as characterized by the alpha/beta-ratio of the photon linear quadratic parameters is expected to be inverted at high doses as compared to low doses.We demonstrate that this inversion is not a model specific feature, but a rather generic feature resulting from the linear-quadratic shape of dose response curves and the correlation between RBE and the photon alpha/beta-ratio. The results are discussed with respect to other modelling approaches and to their implications for clinical applications of carbon ion beams using hypofractionated treatment schedules. (C) 2014 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.