Different effects of peripheral and central ghrelin on regulation of food intake in the Japanese quail
Different effects of peripheral and central ghrelin on regulation of food intake in the Japanese quail
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DOI：
10.1016/j.ygcen.2004.12.021
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发表时间：
2005-04-01
影响因子：
2.7
通讯作者：
Murakami, N
中科院分区：
文献类型：
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作者：
Shousha, S;Nakahara, K;Murakami, N
当老鼠或人类的胃饥饿素被喂给鸡或老鼠时，它会刺激生长激素的释放，然而，它对食物摄入的影响在两个物种之间是不同的。为了研究这种差异，我们测量了进食前后的血浆胃饥饿素浓度，并确定了中央（脑室内，icv）和外周（腹腔内，ip）注射不同剂量的胃饥饿素对日本鹌鹑食物摄入和体温的影响。对照鹌鹑在空腹状态下血浆胃饥饿素水平显著升高；随后的喂食导致了饥饿素的减少，这表明在日本鹌鹑和哺乳动物中，饥饿素可能是一种供氧信号。小剂量的胃饥饿素可以刺激进食，而不是icv，而大剂量的胃饥饿素和icv注射都可以抑制进食。大剂量的胃促生长素也会升高体温。这些结果表明，日本鹌鹑和大鼠一样，外周胃饥饿素的增加可能作为饥饿信号，通过刺激传入迷走神经来诱导食物摄入，而中央胃饥饿素可能以不同的方式抑制两种物种的进食。(c) 2005爱思唯尔公司版权所有。
When rat or human ghrelin is administered to chickens or rats it stimulates the release of growth hormone, however, its effects on food intake differ between the two species. To investigate this discrepancy, we measured plasma ghrelin concentrations before and after food intake, and determined the effects of central (intracerebroventricular, icv) and peripheral (intraperitoneal, ip) injections of various ghrelin doses on food intake and body temperature in the Japanese quail. In control quails, plasma ghrelin levels were significantly increased in the fasting state; subsequent feeding produced a reduction, suggesting that ghrelin may act as an orexigenic signal in Japanese quails as well as mammals. Food intake was stimulated by ip, but not icv, injections of small doses of ghrelin, whereas both ip and icv injections of larger doses inhibited feeding. A large dose of ghrelin also increased body temperature. These results suggest that an increase in peripheral ghrelin may act as a hunger signal to induce food intake through stimulation of the afferent vagal nerve in the Japanese quail, as in rats, whereas central ghrelin may inhibit feeding in different ways in the two species. (c) 2005 Elsevier Inc. All rights reserved.