Patterns of Association between Depressive Symptoms and Chronic Medical Morbidities in Older Adults.
Patterns of Association between Depressive Symptoms and Chronic Medical Morbidities in Older Adults.
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DOI：
10.1111/jgs.16468
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发表时间：
2020-08
影响因子：
6.3
通讯作者：
ASPREE Investigator Group
中科院分区：
文献类型：
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作者：
Agustini B;Lotfaliany M;Woods RL;McNeil JJ;Nelson MR;Shah RC;Murray AM;Ernst ME;Reid CM;Tonkin A;Lockery JE;Williams LJ;Berk M;Mohebbi M;ASPREE Investigator Group
To investigate the association between depressive symptoms and several medical morbidities, and their combination, in a large older population. Cross-sectional study of baseline data from the ASPirin in Reducing Events in the Elderly (ASPREE) trial. Multicentric study conducted in Australia and the United States. A total of 19,110 older adults (mean age = 75 years [standard deviation = ±4.5]). Depressive symptoms were measured using the Center for Epidemiological Studies Depression (CES-D 10) scale. Medical morbidities were defined according to condition-specific methods. Logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs) to test associations before and after accounting for possible confounders. Depressive symptoms were significantly associated with obesity (OR = 1.19; 95% CI = 1.07–1.32), diabetes (OR = 1.22; 95% CI = 1.05–1.42), gastroesophageal reflux disease (GERD) (OR = 1.41; 95% CI = 1.28–1.57), metabolic syndrome (OR = 1.16; 95% CI = 1.03–1.29), osteoarthritis (OR = 1.41; 95% CI = 1.27–1.57), respiratory conditions (OR = 1.25; 95% CI = 1.10–1.42), history of cancer (OR = 1.19; 95% CI = 1.05–1.34), Parkinson’s disease (OR = 2.56; 95% CI = 1.83–3.56), polypharmacy (OR = 1.60; 95% CI = 1.44–1.79), and multimorbidity (OR = 1.29; 95% CI = 1.12–1.49). No significant association was observed between depressive symptoms and hypertension, chronic kidney disease, dyslipidemia, and gout (P > .05). A significant dose-response relationship was evident between the number of medical comorbidities and the prevalence of depression (OR = 1.18; 95% CI = 1.13–1.22). Late-life depressive symptoms are significantly associated with several medical morbidities, and there appears to be a cumulative effect of the number of somatic diseases on the prevalence of depression. These findings augment the evidence for a complex relationship between mental and physical health in an otherwise healthy older population and might guide clinicians toward early recognition of high-risk individuals.
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影响因子：
10.8
作者：
Leone T;Coast E;Narayanan S;de Graft Aikins A
通讯作者：
de Graft Aikins A
影响因子：
2.2
作者：
ASPREE Investigator Group
通讯作者：
ASPREE Investigator Group
影响因子：
--
作者：
Irwin, M;Artin, KHH;Oxman, MN
通讯作者：
Oxman, MN
影响因子：
6.6
作者：
Marijnissen, Radboud M.;Smits, Johanna E. M. P.;Voshaar, Richard C. Oude
通讯作者：
Voshaar, Richard C. Oude
影响因子：
120.7
作者：
Bruce, ML;Ten Have, TR;Alexopoulos, GS
通讯作者：
Alexopoulos, GS