Intratumoral T but not B lymphocytes are related to clinical outcome in prostate cancer
Intratumoral T but not B lymphocytes are related to clinical outcome in prostate cancer
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DOI：
10.1111/j.1600-0463.2012.02924.x
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发表时间：
2012-11-01
期刊：
影响因子：
2.8
通讯作者：
Trepel, Martin
中科院分区：
文献类型：
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作者：
Flammiger, Anna;Bayer, Florian;Trepel, Martin
肿瘤浸润淋巴细胞的数量在功能上是重要的，并与几种肿瘤实体的临床结果相关。在此，我们探讨前列腺癌组织中T和B淋巴细胞密度对前列腺特异性抗原（PSA）复发的影响，在3261例前列腺癌组织样本中进行前列腺切除术后。通过免疫组织化学测定组织微阵列格式中每个组织点的前列腺癌浸润性CD 3阳性T细胞和CD 20阳性B细胞的数量，并将其与来自同一患者队列的临床和病理学数据相关联。与具有中等数量T细胞的患者相比，每个组织点具有非常低和非常高数量的CD3阳性T细胞的患者具有显著较短的PSA无复发生存期（p=0.0188）。此外，每个组织点的大量CD3阳性T细胞与通过ERG表达分析鉴定的融合型前列腺癌相关。每个组织点的CD 20阳性B细胞数与其他临床和组织病理学参数无关。这项研究表明，T细胞而不是B细胞的密度在前列腺癌的生物学中起着重要作用，并可能对这种常见肿瘤的临床结果产生影响。
The number of tumor-infiltrating lymphocytes is functionally important and correlates with clinical outcome in several tumor entities. Herein we explore the impact of the density of T and B lymphocytes in prostate cancer tissue on prostate-specific antigen (PSA) recurrence after prostatectomy in 3261 prostate cancer tissue samples. The number of prostate cancer-infiltrating CD3-positive T cells and CD20-positive B cells per tissue spot in a tissue microarray format was determined by immunohistochemistry and was correlated with clinical and pathological data from the same patient cohort. Patients with very low and very high numbers of CD3-positive T cells per tissue spot had a significantly shorter PSA recurrence-free survival compared to patients with intermediate numbers of T cells (p=0.0188). Furthermore, a high number of CD3-positive T cells per tissue spot was associated with fusion type prostate cancer identified by ERG expression analysis. The number of CD20-positive B cells per tissue spot was not associated with other clinical and histopathological parameters. This study indicates that the density of T but not B cells plays a functional role in the biology of prostate cancer and may have an impact on clinical outcome in this frequent neoplasia.