Pattern of Methamphetamine Use and the Time Lag to Methamphetamine Dependence.
Pattern of Methamphetamine Use and the Time Lag to Methamphetamine Dependence.
复制标题
甲基苯丙胺的使用模式和甲基苯丙胺依赖的时间滞后。
DOI：
10.1097/adm.0000000000000371
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发表时间：
2018
影响因子：
5.5
通讯作者：
Kalayasiri,Rasmon
中科院分区：
文献类型：
--
作者：
Yimsaard,Pongkwan;Maes,MichaelM;Verachai,Viroj;Kalayasiri,Rasmon
目的：甲基苯丙胺(MA)的使用通常与其他物质的使用同时发生。本研究旨在检验吸毒者中酒精、尼古丁、吸入剂和大麻(OTH)等其他物质的物质起始模式及其对吸毒者依赖时间延迟的影响。方法：从泰国物质治疗中心吸毒者那里获得社会人口学、环境和临床数据。结果：991例吸毒者中，男性占52.6%，平均年龄26.8±7.1岁。首次使用吸食大麻的平均年龄(18岁)高于首次使用酒精(17岁)、尼古丁(16岁)和吸入剂(15岁)的平均年龄(P<；0.001)，但与首次使用大麻的平均年龄相当(P>；0.05)。MA使用家族史和尼古丁依赖与MA早期发病相关。使用MA作为他们的第一种药物(MA和GT；OTH)的参与者比那些使用MA晚于其他物质(OTH和GT；MA)的参与者更有可能是女性，不太可能强烈吸烟和暴露于严重的创伤事件中。从使用MA开始到依赖的时间，OTH和GT；MA组比MA>；MA组短(3年比5年；χ2=5.7，P=0.0 2，对数列检验)。结论：MA和GT；MA组女性比例高于OTH&>MA组。在MA治疗队列中，在MA之前使用其他物质增加了个人在缩短MA使用开始年龄和MA依赖之间的间隔方面的脆弱性。
Objectives:Use of methamphetamine (MA) commonly co-occurs with the use of other substances. The present study aims to examine substance initiation patterns of other substances, including alcohol, nicotine, inhalants, and cannabis (OTH), in MA users and its consequence on the time lag of MA dependence.Methods:Sociodemographic, environmental, and clinical data were obtained from MA users at a Thai substance treatment center. The Semi-Structured Assessment for Drug Dependence and Alcoholism was employed to diagnose drug dependence.Results:Of 991 MA users, 52.6% were males, and the average age was 26.8±7.1 years. The mean age of first MA use (18 years) was greater than the mean age of first use of alcohol (17 years), nicotine (16 years), and inhalants (15 years)(P< 0.001), but was comparable with the mean age at the first use of cannabis (P> 0.05). Family history of MA use and nicotine dependence were associated with early MA onset. Participants who used MA as their first drug (MA> OTH) were more likely to be female and less likely to smoke intensely and to be exposed to severe traumatic events than those who used MA later than other substances (OTH> MA). The time lag from age at onset of MA use to MA dependence was shorter in OTH> MA than in MA> OTH (3 vs 5 years; χ 2= 5.7, P= 0.02, log-rank test).Conclusions:A higher proportion of women was observed in MA> OTH than in OTH> MA. The use of other substances before MA increases the individual's vulnerability in shortening the interval between age at onset of MA use and MA dependence in a substance treatment cohort.