Actin bundling: initiation mechanisms and kinetics.
Actin bundling: initiation mechanisms and kinetics.
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DOI：
10.1103/physrevlett.101.128102
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发表时间：
2008-09-19
影响因子：
8.6
通讯作者：
Novak IL
中科院分区：
文献类型：
--
作者：
Kraikivski P;Slepchenko BM;Novak IL
Bundling of rapidly polymerizing actin filaments underlies dynamics of filopodial protrusions that play an important role in cell migration and cell-cell interaction. Recently, formation of actin bundles has been reconstituted in vitro and two scenarios of bundle initiation, involving binding of two filament tips and, alternatively, linking of the tip of one filament to the side of the other, -have been discussed. A first theoretical analysis is presented indicating that the two mechanisms can be distinguished experimentally. While both of them result counter-intuitively in comparable numbers of bundles, these numbers scale differently with the average bundle length. We propose an experiment for determining which of the two mechanisms is involved in the in vitro bundle formation.
