Melanoma biology and the promise of zebrafish.
Melanoma biology and the promise of zebrafish.
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DOI:
10.1089/zeb.2008.0544
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发表时间:
2008-12
期刊:
影响因子:
2
通讯作者:
Zon LI
中科院分区:
文献类型:
--
作者:
Ceol CJ;Houvras Y;White RM;Zon LI
Advantageous organismal and technical attributes of the zebrafish are being increasingly applied to study cancer biology. Along with other tumor models, zebrafish that develop melanomas have been generated. In both genetics and phenotype, zebrafish melanomas are strikingly similar to their human counterparts. For this reason, studies in the zebrafish are poised to make significant contributions to melanoma biology. In this review, we summarize important features of human melanoma and discuss how the zebrafish can be used to address many questions that remain unanswered about this devastating disease.
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