Melanoma biology and the promise of zebrafish.

Melanoma biology and the promise of zebrafish.
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DOI:
10.1089/zeb.2008.0544
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发表时间:
2008-12
期刊:
影响因子:
2
通讯作者:
Zon LI
Zon LI
中科院分区:
生物学4区
文献类型:
--
作者:
Ceol CJ;Houvras Y;White RM;Zon LI

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斑马鱼优越的机体和技术特性正越来越多地应用于癌症生物学研究。与其他肿瘤模型一样,斑马鱼也产生了黑色素瘤。在遗传和表型上,斑马鱼的黑色素瘤与人类的黑色素瘤惊人地相似。因此,对斑马鱼的研究有望对黑色素瘤生物学做出重大贡献。在这篇综述中,我们总结了人类黑色素瘤的重要特征,并讨论了如何利用斑马鱼来解决关于这种毁灭性疾病的许多尚未解决的问题。
Advantageous organismal and technical attributes of the zebrafish are being increasingly applied to study cancer biology. Along with other tumor models, zebrafish that develop melanomas have been generated. In both genetics and phenotype, zebrafish melanomas are strikingly similar to their human counterparts. For this reason, studies in the zebrafish are poised to make significant contributions to melanoma biology. In this review, we summarize important features of human melanoma and discuss how the zebrafish can be used to address many questions that remain unanswered about this devastating disease.
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