Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase
Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase
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DOI：
10.1194/jlr.c200010-jlr200
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发表时间：
2002-11-01
影响因子：
6.5
通讯作者：
Furukawa, H
中科院分区：
文献类型：
--
作者：
Yoshida, K;Shimizugawa, T;Furukawa, H
对具有独特低甘油三酯血症表型的KK/SAN、肥胖和糖尿病模型小鼠的研究表明，血管生成素样蛋白3(Angptl3)调节小鼠的脂代谢。为了确定其他ANGPTL的调脂作用，我们重点研究了ANGPTL4，它总体上与Angptl3有显著的相似性。令人惊讶的是，KK/SAN小鼠静脉注射ANGPTL4蛋白后，循环血脂水平迅速上升的速度高于Angptl3蛋白。此外，ANGPTL4蛋白在体外对脂蛋白脂酶活性有抑制作用。
Studies with KK/San, obese and diabetic model mice having a unique hypotriglyceridemia phenotype, revealed that angiopoietin-like protein 3 (ANGPTL3) regulates lipid metabolism in mice. To determine the lipid-modulating role of other ANGPTLs, we focused on ANGPTL4, which overall shows a significant similarity to ANGPTL3. Surprisingly, an intravenous injection of the ANGPTL4 protein in KK/San mice rapidly increased the circulating plasma lipid levels at a higher rate than ANGPTL3 protein. Furthermore, the ANGPTL4 protein inhibited the lipoprotein lipase activity in vitro.