Effects of fructans-type prebiotics on lipid metabolism
Effects of fructans-type prebiotics on lipid metabolism
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DOI：
10.1093/ajcn/73.2.456s
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发表时间：
2001-02-01
影响因子：
7.1
通讯作者：
Kok, N
中科院分区：
文献类型：
--
作者：
Delzenne, NM;Kok, N
几种不易消化但可发酵的膳食碳水化合物能够调节人类和动物的脂血症和三酸甘油酯血症。其降血脂作用的机制仍有待阐明。低聚果糖是一种不易消化和可发酵的果聚糖的混合物，当给予大鼠时，可以降低VLDL中的三酰甘油。低聚果糖降低三酰甘油的作用是由于通过抑制所有脂肪生成酶，即乙酰辅酶A羧化酶（EC 6.4.1.2）、脂肪酸合成酶、苹果酸酶（EC 4.1.3.8）、ATP柠檬酸裂解酶（EC www.example.com）和葡萄糖-6-磷酸脱氢酶（EC 1.1.1.49），减少肝脏中的从头脂肪酸合成。1.1.1.40我们的研究结果表明，低聚果糖降低脂肪生成酶基因的表达。低聚果糖喂养动物的血清中餐后胰岛素和葡萄糖浓度较低，这至少可以部分解释低聚果糖的代谢效应。此外，低聚果糖喂养后胃肠道中发生的一些事件可能与这种果聚糖的抗脂肪生成作用有关：通过发酵产生丙酸盐，调节肠促胰岛素（即葡萄糖依赖性促胰岛素肽和胰高血糖素样肽-1）的肠道产生，或修改可消化碳水化合物的可用性。最近的研究表明，果聚糖的低血糖作用也发生在人类身上。
Several nondigestible but fermentable dietary carbohydrates are able to regulate lipemia and triglyceridemia in both humans and animals. The mechanism of their serum lipid-lowering effect remains to be elucidated. Oligofructose, which is a mixture of nondigestible and fermentable fructans, can decrease triacylglycerol in VLDL when given to rats. The triacylglycerol-lowering action of oligofructose is due to a reduction of de novo fatty acid synthesis in the liver through inhibition of all lipogenic enzymes, namely acetyl-CoA carboxylase (EC 6.4.1.2), fatty acid synthase, malic enzyme (EC 1.1.1.40), ATP citrate lyase (EC 4.1.3.8), and glucose-6-phosphate dehydrogenase (EC 1.1.1.49). Our results suggest that oligofructose decreases lipogenic enzyme gene expression. Postprandial insulin and glucose concentrations are low in the serum of oligofructose-fed animals and this could explain, at least partially, the metabolic effect of oligofructose. Moreover, some events occurring in the gastrointestinal tract after oligofructose feeding could be involved in the antilipogenic effect of this fructan: the production of propionate through fermentation, a modulation of the intestinal production of incretins (namely glucose-dependent insulinotropic peptide and glucagon-like peptide-1), or the modification of the availability of digestible carbohydrates. Recent studies showed that the hypotriglyceridemic effect of fructans also occurs in humans.