Cognitive and clinical outcomes associated with cannabis use in patients with bipolar I disorder
Cognitive and clinical outcomes associated with cannabis use in patients with bipolar I disorder
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DOI：
10.1016/j.psychres.2012.05.025
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发表时间：
2012-12-30
影响因子：
11.3
通讯作者：
Malhotra, Anil K.
中科院分区：
文献类型：
--
作者：
Braga, Raphael J.;Burdick, Katherine E.;Malhotra, Anil K.
调查大麻使用对双相临床特征和神经认知影响的研究有限。本研究的目的是比较大麻使用障碍（CUD）与那些没有CUD历史的双相情感障碍患者的临床和神经认知措施。我们对一个大型队列（N=200）的双相I型受试者进行了回顾性分析，包括有（CUD+; N=50）或无（CUD-; N=150）CUD病史的受试者。我们比较了两组的临床和人口统计学变量，以及神经认知测试的表现。患者组在年龄、发病年龄或总体功能评估方面没有差异。与CUD -组相比，CUD+组的男性比例更高，有精神病史的患者比例更高。CUD+受试者在注意力、处理速度和工作记忆方面表现出明显更好的表现。CUD病史与精神病史相关，提示临床预后较差。有趣的是，与没有CUD病史的患者相比，有CUD病史的双相情感障碍患者的神经认知表现更好。(C)2012爱思唯尔爱尔兰有限公司保留所有权利。
Studies investigating the impact of cannabis use on bipolar clinical characteristics and neurocognition are limited. The objective of the present study was to compare clinical and neurocognitive measures in individuals with bipolar disorder with a history of cannabis use disorder (CUD) versus those without a history of CUD. We conducted a retrospective analysis of a large cohort (N=200) of bipolar I subjects, either with (CUD+; N=50) or without (CUD-; N=150) a history of CUD. We compared the groups on clinical and demographic variables, as well as on performance on neurocognitive tests. Patient groups did not differ regarding age, age of onset or global assessment of functioning. Compared to the CUD - group, the CUD+ group had a higher proportion of men and a higher proportion of patients with a history of psychosis. CUD+ subjects demonstrated significantly better performance on measures of attention, processing speed, and working memory. The history of CUD is associated with history of psychosis, suggestive of poorer clinical prognosis. Interestingly, bipolar patients with history of CUD had better neurocognitive performance as compared to patients with no history of CUD. (C) 2012 Elsevier Ireland Ltd. All rights reserved.