Separate mechanical processes underlie fast and slow effects of medial olivocochlear efferent activity
Separate mechanical processes underlie fast and slow effects of medial olivocochlear efferent activity
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单独的机械过程是内侧橄榄耳蜗传出活动的快速和缓慢影响的基础
DOI：
10.1111/j.1469-7793.2003.00307.x
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
J. Guinan
中科院分区：
文献类型：
--
作者：
Nigel P. Cooper;J. Guinan
麻醉豚鼠的基底膜（BM）的声诱发振动被证明在两个不同的时间尺度上受到内侧橄榄耳蜗传出系统的电刺激的影响：一个是快的（10-100 ms），另一个要慢得多（10-100 s）。对于低和中等水平的音调附近的BM的特征频率，快速和缓慢的影响抑制BM的运动。然而，快速抑制伴随着相位超前，而缓慢抑制伴随着相位滞后。这些发现与一个假设是一致的，即快速和缓慢的影响，减少声音在耳蜗放大。然而，相变的相反方向表明，不同的机械过程必须基于快速和缓慢的影响。对这些发现的一种合理解释是，传出慢效应是由外毛细胞刚度降低引起的，而传出快效应是由“负阻尼”减少引起的。
Sound‐evoked vibrations of the basilar membrane (BM) in anaesthetised guinea‐pigs are shown to be affected over two distinct time scales by electrical stimulation of the medial olivocochlear efferent system: one is fast (10–100 ms), the other much slower (10–100 s). For low and moderate level tones near the BM's characteristic frequency, both fast and slow effects inhibited BM motion. However, fast inhibition was accompanied by phase leads, while slow inhibition was accompanied by phase lags. These findings are consistent with a hypothesis that both fast and slow effects decrease sound amplification in the cochlea. However, the opposing directions of the phase changes indicate that separate mechanical processes must underlie fast and slow effects. One plausible interpretation of these findings is that efferent slow effects are caused by outer‐hair‐cell stiffness decreases, while efferent fast effects are caused by reductions in ‘negative damping’.
内侧传出对听觉神经对尾频音调反应的影响。
DOI：
10.1121/1.427102
发表时间：
1999
期刊：
The Journal of the Acoustical Society of America
影响因子：
--
作者：
Stankovic,KM;GuinanJr,JJ
通讯作者：
GuinanJr,JJ
影响因子：
2.5
作者：
Hallworth, R
通讯作者：
Hallworth, R
传出介导的声音过度暴露保护：与橄榄耳蜗刺激的缓慢影响有关。
DOI：
10.1152/jn.1995.73.2.506
发表时间：
1995
期刊：
Journal of neurophysiology.
影响因子：
--
作者：
Reiter,ER;Liberman,MC
通讯作者：
Liberman,MC