Circulating Matrix Metalloproteinase-2 Is an Independent Correlate of Proteinuria in Patients with Chronic Kidney Disease
Circulating Matrix Metalloproteinase-2 Is an Independent Correlate of Proteinuria in Patients with Chronic Kidney Disease
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DOI：
10.1159/000151439
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发表时间：
2009-01-01
影响因子：
4.2
通讯作者：
Okuda, Seiya
中科院分区：
文献类型：
--
作者：
Nagano, Makio;Fukami, Kei;Okuda, Seiya
背景/目的：基质金属蛋白酶-2 （MMP-2）与慢性肾脏疾病（CKD）和心血管疾病有关。然而，CKD患者血清MMP-2水平、蛋白尿和动脉粥样硬化之间的相关性尚不清楚。我们研究了CKD患者血清MMP-2水平是否与蛋白尿、内膜中膜厚度（IMT）和颈动脉粥样硬化斑块的存在相关。方法：纳入无血液透析的CKD患者（n = 99）。ELISA检测MMP-2水平。采用高分辨率超声检查IMT和颈动脉粥样硬化斑块。结果：多因素分析显示，低密度脂蛋白（p < 0.001）、MMP-2 （p = 0.001）和收缩压（p = 0.011）是蛋白尿的独立相关因素。年龄和血清肌酐调整的MMP-2水平与蛋白尿水平的增加成比例显著升高（p = 0.001）。此外，年龄（p < 0.001）、收缩压（p = 0.015）和MMP-2水平（p = 0.042）是IMT的独立相关因素。动脉粥样硬化斑块患者的MMP-2水平明显高于无斑块患者（p < 0.01）。结论：本研究表明血清MMP-2水平是CKD患者蛋白尿和IMT的独立相关因素之一。我们的研究结果提示血清MMP-2水平可能是CKD患者肾损害和动脉粥样硬化的危险因素之一。版权所有2008 S. Karger AG，巴塞尔
Background/Aim: Matrix metalloproteinase-2 (MMP-2) has been implicated in chronic kidney disease (CKD) and cardiovascular disease. However, there is no knowledge about the correlations between serum levels of MMP-2, proteinuria and atherosclerosis in patients with CKD. We investigated whether serum MMP-2 levels were associated with proteinuria, intima media thickness (IMT), and the presence of carotid atherosclerotic plaque in CKD patients. Methods: CKD patients without hemodialysis (n = 99) were enrolled. MMP-2 levels were measured by an ELISA system. IMT and carotid atherosclerotic plaque were evaluated by a high-resolution ultrasonography. Results: Multivariate analyses revealed that low-density lipoprotein (p < 0.001), MMP-2 (p = 0.001) and systolic blood pressure (p = 0.011) were independent correlates of proteinuria. Age- and serum creatinine-adjusted MMP-2 levels were significantly increased (p = 0.001) in proportion to the increasing levels of proteinuria. Further, age (p < 0.001), systolic blood pressure (p = 0.015) and MMP-2 levels (p = 0.042) were independent correlates of IMT. MMP-2 levels were significantly (p < 0.01) higher in patients with atherosclerotic plaque than those without it. Conclusions: The present study demonstrated that serum levels of MMP-2 were one of the independent correlates of proteinuria and IMT in patients with CKD. Our results suggest that serum MMP-2 levels may be one of the risk factors for renal damage and atherosclerosis in CKD patients. Copyright (C) 2008 S. Karger AG, Basel