Understanding the pathogenesis and management of hepatitis B/HIV and hepatitis B/hepatitis C virus coinfection.
Understanding the pathogenesis and management of hepatitis B/HIV and hepatitis B/hepatitis C virus coinfection.
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DOI：
10.1016/j.cld.2007.08.007
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发表时间：
2007-11-01
影响因子：
5.1
通讯作者：
Talal, Andrew H
中科院分区：
文献类型：
--
作者：
Cheruvu, Srinivas;Marks, Kristen;Talal, Andrew H
治疗同时感染HIV或HCV的B型肝炎病毒（HBV）感染患者的方法与治疗仅感染一种病毒的患者的方法非常不同。HBV/HIV合并感染很常见。在开始抗逆转录病毒治疗的HBV/HIV合并感染患者中，应考虑将具有抗HBV和HIV双重活性的药物作为联合方案的治疗选择。在乙型肝炎病毒/丙型肝炎病毒合并感染中，丙型肝炎病毒通常倾向于比乙型肝炎病毒占主导地位。需要更多的研究病毒的发病机制是如何改变和最佳的治疗模式，为合并感染的患者。
The approach to the hepatitis B virus (HBV)-infected patient who is also infected with HIV or hepatitis C virus (HCV) is very different from the approach to the patient with only one virus infection. HBV/HIV coinfection is common. Agents that have dual activity against HBV and HIV should be considered as treatment of choice in combination regimens in HBV/HIV-coinfected patients beginning antiretroviral therapy. In HBV/HCV coinfection HCV usually tends to predominate over HBV. More investigation is needed into the mechanisms by which viral pathogenesis is altered and the optimal treatment modalities for coinfected patients.