The clinical free radical scavenger, edaravone, protects cochlear hair cells from acoustic trauma
The clinical free radical scavenger, edaravone, protects cochlear hair cells from acoustic trauma
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DOI：
10.1016/j.ejphar.2004.01.019
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发表时间：
2004-03-08
影响因子：
5
通讯作者：
Yamashita, H
中科院分区：
文献类型：
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作者：
Takemoto, T;Sugahara, K;Yamashita, H
已知活性氧对耳蜗具有毒性。我们研究了临床使用的自由基清除剂依达拉奉对声损伤豚鼠耳蜗的影响。方法：采用听性脑干反应（ABR）阈值评价耳蜗功能，并对耳蜗感觉上皮进行观察。噪声暴露（130 dB SPL，3 h）后，依达拉奉治疗组听性脑干反应阈移明显小于未治疗组。该结果表明依达拉奉保护耳蜗免受声损伤。(C)2004 Elsevier B.V.保留所有权利。
It is known that reactive oxygen species have toxicity to the cochlea. We investigated the effect of edaravone, a free radical scavenger for clinical use, on the cochleae of guinea pigs subjected to acoustic trauma. We assessed auditory brainstem response (ABR) thresholds to evaluate cochlear function and observed the sensory epithelium. After noise exposure (130 dB SPL, 3 h), we observed that the auditory brainstem response threshold shift in edaravone-treated ears was significantly less than that in untreated ears. This result suggests that edaravone protected the cochleae from acoustic trauma. (C) 2004 Elsevier B.V. All rights reserved.