Intravenous Amiodarone for Therapy of Atrial Fibrillation and Flutter in Critically Ill Patients With Severely Depressed Left Ventricular Function
Intravenous Amiodarone for Therapy of Atrial Fibrillation and Flutter in Critically Ill Patients With Severely Depressed Left Ventricular Function
复制标题
静脉注射胺碘酮治疗左心室功能严重抑制的危重患者心房颤动和扑动
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发表时间：
1996
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通讯作者：
Amit Kumar
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文献类型：
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作者：
Amit Kumar
回顾性分析了有创监测急性心房颤动或心房扑动且左室射血分数<15%的患者缓慢静脉注射胺碘酮的疗效和血流动力学影响。8例患者符合预定的纳入标准。所有患者均在1小时内静脉注射300毫克胺碘酮。7例在1小时内恢复窦性心律，大多数血流动力学指标恢复到基线。在逆转之前，每个患者都经历了有益的心率减慢（平均28%），导致卒中容量指数（平均49%）和左室卒中工作指数（平均61%）的显著改善。无患者因胺碘酮输注导致血流动力学恶化。缓慢静脉滴注胺碘酮似乎是一种有效且血流动力学耐受良好的治疗左心室收缩功能明显下降的危重患者心房颤动和心房扑动的方法。
A retrospective review was done to determine the efficacy and hemodynamic effects of slow intravenous amiodarone administration on invasively monitored patients with acute onset of atrial fibrillation or atrial flutter and left ventricular ejection fractions <15%. Eight patients met predefined inclusion criteria. All received 300 mg amiodarone intravenously over 1 hour. Seven reverted to sinus rhythm within 1 hour, with return of most hemodynamic variables to baseline. Before reversion, each patient experienced a beneficial slowing of heart rate (mean, 28%) resulting in significant improvement of stroke volume index (mean, 49%) and left ventricular stroke work index (mean, 61%). No patient had hemodynamic deterioration attributable to amiodarone infusion. Slow intravenous infusion of amiodarone appears to be an effective and hemodynamically well–tolerated therapy for atrial fibrillation and atrial flutter in critically ill patients with marked depression of left ventricular systolic function.