Cortisol, hunger, and desire to binge eat following a cold stress test in obese women with binge eating disorder
Cortisol, hunger, and desire to binge eat following a cold stress test in obese women with binge eating disorder
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DOI：
10.1097/01.psy.0000143637.63508.47
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发表时间：
2004-11-01
影响因子：
3.3
通讯作者：
Yahav, E
中科院分区：
文献类型：
--
作者：
Gluck, ME;Geliebter, A;Yahav, E
目的：神经性贪食症患者基础皮质醇水平升高。在压力之后，皮质醇水平的增加与健康女性的食物摄入量增加有关。因此，我们评估了患有暴食症（BED）的女性在冷加压试验（CPT）后的皮质醇、饥饿和暴食欲望。研究方法：22名肥胖（体重指数[BMI] = 36.7 +/-6.5SD）女性（I I非BED，I I BED）完成Zung抑郁量表并进行CPT，将手浸没在冰水中2分钟。在60分钟内，在抽取皮质醇和胰岛素的血液之前，定期获得饥饿和暴食欲望的评级。在另一天，参与者进行1 mg口服地塞米松抑制试验（DST）。结果如下：BED组的抑郁评分高于非BED组（p = 0.04），但抑郁不是皮质醇反应或DST的显著协变量。在控制避孕措施使用后（n = 3），BED组的基础皮质醇高于非BED组（p = 0.03），但DST后皮质醇没有差异（p = 0.40）。在控制胰岛素AUC和避孕药使用（p =.057）后，BED组CPT后的皮质醇AUC几乎显著更高（p =.057）。CPT后，BED组的饥饿（p = .03）和暴饮暴食（p = .02）的AUC也更大。结论：这些发现支持我们的假设，一个过度活跃的HPA轴在床上，这可能有助于更大的饥饿和暴食。
Objective: Increased basal cortisol levels have been found in bulimia nervosa. After stress, increased cortisol levels have been associated with increased food intake in healthy women. Therefore, we assessed cortisol, hunger, and desire to binge eat after a cold pressor test (CPT) among women with binge eating disorder (BED). Methods: Twenty-two obese (body mass index [BMI] = 36.7 +/- 6.5 SD) females (I I non-BED, I I BED) completed the Zung depression scale and underwent the CPT, hand submerged in ice water for 2 minutes. Over 60 minutes, periodic ratings of hunger and desire to binge eat were obtained, just before blood draws for cortisol, as well as insulin. On a separate day, participants bad a 1-mg oral dexamethasone suppression test (DST). Results: The BED group had higher depression scores than the non-BED (p = .04), but depression was not a significant covariate for the cortisol response or to DST. After controlling for contraceptive use (n = 3), the BED group had higher basal cortisol than the non-BED group (p = .03), but cortisol did not differ after DST (p = .40). The BED group had nearly significant greater cortisol AUC after the CPT (p = .057) after controlling for insulin AUC and contraceptive use (p = .057). The BED group also had greater AUC for hunger (p = .03) and desire to binge eat (p = .02) after the CPT. Conclusion: These findings support our hypothesis of a hyperactive HPA-axis in BED, which may contribute to greater hunger and binge eating.