Immune interference after sequential alphavirus vaccine vaccinations
Immune interference after sequential alphavirus vaccine vaccinations
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DOI：
10.1016/j.vaccine.2009.02.090
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发表时间：
2009-08-06
期刊：
影响因子：
5.5
通讯作者：
Gibbs, Paul H.
中科院分区：
文献类型：
--
作者：
Pittman, Phillip R.;Liu, Ching-Tong;Gibbs, Paul H.
我们比较了试验用甲病毒疫苗的接种顺序对中和抗体应答的影响。在委内瑞拉减毒活疫苗（VEE）之前接受灭活东部和西部马脑炎（EAE和WEE）疫苗的志愿者的抗体应答率显著低于在EAE和WEE疫苗之前接受VEE疫苗的志愿者（66.7% vs. 80.6%; p = 0.026）。根据性别调整后，最初接受抗逆转录病毒疫苗和WEE疫苗的患者中，VEE抗体无应答的几率很大（比值比[OR] = 2.20; 95% CI = 1.2-4.1 [p = 0.0145]），调整组的女性无应答的比值也是如此（OR = 1.81; 95% CI = 1.2-2.7 [p = 0.0037]）。抗体干扰和性别效应对接受多种甲病毒疫苗的人和为这些威胁开发下一代疫苗的人的疫苗策略具有重大影响。(C)2009年由Elsevier Ltd.出版
We compared the effect of order of administration of investigational alphavirus vaccines on neutralizing antibody response. Volunteers who received the inactivated eastern and western equine encephalitis (EEE and WEE) vaccines before live attenuated Venezuelan (VEE) vaccine had significantly lower rates of antibody response than those receiving VEE vaccine before EEE and WEE vaccines (66.7% vs. 80.6%; p = 0.026). The odds of having a VEE antibody non-response among those initially receiving EEE and WEE vaccines, adjusted for gender, were significant (odds ratio [OR] = 2.20; 95% CI = 1.2-4.1 [p = 0.0145]) as were the odds of non-response among females adjusted for group (OR = 1.81; 95% CI = 1.2-2.7 [p = 0.0037]). Antibody interference and gender effect have major implications for vaccine strategy among those receiving multiple alphavirus vaccines and those developing next generation vaccines for these threats. (C) 2009 Published by Elsevier Ltd.