Effects of phospholipids on antiganglioside antibody reactivity in GBS
Effects of phospholipids on antiganglioside antibody reactivity in GBS
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DOI：
10.1016/j.jneuroim.2004.09.018
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发表时间：
2005-02-01
影响因子：
3.3
通讯作者：
Kusunoki, S
中科院分区：
文献类型：
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作者：
Hirakawa, M;Morita, D;Kusunoki, S
在30例抗GM1 IgG阳性GBS患者和30例抗GQ1b IgG阳性米勒费舍尔综合征（MFS）患者中，将神经节苷脂和各种磷脂混合物的血清抗体活性与单独神经节苷脂的血清抗体活性进行比较。抗GM 1阳性血清对GM 1和几种磷脂（包括PA、PI和PS）的混合物的抗体反应性高于单独对GM 1的抗体反应性。相反，在抗GQ1b抗体的情况下，没有磷脂提供显著增强。鞘磷脂降低抗GM1和抗GQ1b IgG的活性。必须考虑磷脂的影响，以确定抗神经节苷脂抗体在GBS和MFS中的致病作用。(C)2004 Elsevier B.V.保留所有权利。
Serum antibody activities to mixtures of a ganglioside and various phospholipids were compared with those to a ganglioside alone in 30 anti-GM1 IgG-positive GBS patients and 30 anti-GQ1b IgG-positive Miller Fisher syndrome (MFS) patients. Anti-GM1-positive sera had higher antibody reactivities against a mixture of GM1 and several phospholipids including PA, PI and PS, than against GM1 alone. In contrast, in case of anti-GQ1b antibody, no phospholipid provided significant enhancement. Sphingomyelin provided decrease of the activity for both anti-GM1 and anti-GQ1b IgG. The effects of phospholipids must be considered to determine the pathogenetic role of antiganglioside antibodies in GBS and MFS. (C) 2004 Elsevier B.V. All rights reserved.