Mixed Pneumococcal-Nontypeable Haemophilus influenzae Otitis Media Is a Distinct Clinical Entity With Unique Epidemiologic Characteristics and Pneumococcal Serotype Distribution
Mixed Pneumococcal-Nontypeable Haemophilus influenzae Otitis Media Is a Distinct Clinical Entity With Unique Epidemiologic Characteristics and Pneumococcal Serotype Distribution
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DOI：
10.1093/infdis/jit289
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发表时间：
2013-10-01
影响因子：
6.4
通讯作者：
Givon-Lavi, Noga
中科院分区：
文献类型：
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作者：
Dagan, Ron;Leibovitz, Eugene;Givon-Lavi, Noga
背景复杂性（即复发性、无反应性或慢性）中耳炎（OM）很常见，通常由混合病原体感染伴生物膜形成引起。我们进行了这项研究，以确定由于肺炎链球菌和不可分型流感嗜血杆菌（NTHi）混合感染（NTHi）而导致OM的儿童以及由于单一S。肺炎球菌纯感染（S-OM），并检查是否与M-OM相关的肺炎球菌血清型与S-OM相关的血清型不同。在以色列南部进行的一项为期10年的前瞻性研究中，将与M-OM相关的临床和人口统计学变量以及儿童中与S-OM相关的肺炎球菌血清型进行了比较
Background. Complex (ie, recurrent, nonresponsive, or chronic) otitis media (OM) is frequent and is often caused by a mixed-pathogen infection with biofilm formation. We conducted this study to characterize children with OM due to mixed Streptococcus pneumoniae and nontypeable Haemophilus influenzae (NTHi) infections (MOM) and those with OM due to single, S. pneumoniae-only infections (S-OM) and to examine whether pneumococcal serotypes associated with M-OM differed from those associated with S-OM.Methods. In a 10-year prospective study in southern Israel, the clinical and demographic variables and pneumococcal serotypes associated with M-OM were compared to those associated with S-OM in children