The efficacy of a hydroxyapatite composite as a biodegradable antibiotic delivery system
The efficacy of a hydroxyapatite composite as a biodegradable antibiotic delivery system
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DOI：
10.1097/01.blo.0000130268.27024.c1
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发表时间：
2004-07-01
影响因子：
4.2
通讯作者：
Ovatlarnporn, C
中科院分区：
文献类型：
--
作者：
Buranapanitkit, B;Srinilta, V;Ovatlarnporn, C
局部可生物降解载体已被研究用作骨骼药物递送系统。本研究探讨了由羟基磷灰石、巴黎石膏和浸有抗生素的壳聚糖组成的局部可生物降解复合材料治疗耐甲氧西林金黄色葡萄球菌的功效。复合材料，浸渍万古霉素，磷霉素，或夫西地酸钠进行了测试，其持续洗脱特性在3个月内，并与类似浸渍聚甲基丙烯酸甲酯使用改进的光盘扩散技术进行了比较。采用扫描电子显微镜和x射线衍射分析了各制剂的理化性质。万古霉素和磷霉素掺入到羟基磷灰石复合物中抑制生物体3个月，而夫西地酸钠仅有效3周。万古霉素和磷霉素负载到羟基磷灰石复合材料具有显着更好的抑制效果比当负载在聚甲基丙烯酸甲酯，而夫西地酸钠负载在聚甲基丙烯酸甲酯表现出显着更好的抑制效果比当负载在羟基磷灰石复合材料。扫描电子显微镜和x射线衍射分析阐明了每种药物释放曲线的模式。局部羟基磷灰石复合材料是万古霉素和磷霉素的一种有前途的局部生物降解给药系统，而PMMA是夫西地酸钠治疗耐甲氧西林金黄色葡萄球菌骨髓炎的一种较好载体。
Local biodegradable carriers have been studied for use as a skeletal drug delivery system. This study investigated the efficacy of a local biodegradable composite composed of hydroxyapatite, plaster of Paris, and chitosan impregnated with antibiotics to treat methicillin-resistant Staphylococcus aureus. The composite, impregnated with vancomycin, fosfomycin, or sodium fusidate was tested for its sustained elution characteristics during 3 months and compared with similarly impregnated polymethylmethacrylate using the modified disc diffusion technique. Physicochemical properties using scanning electron microscopy and xray diffraction analysis of each preparation also were analyzed. Vancomycin and fosfomycin incorporated into the hydroxyapatite composite inhibited the organism for 3 months, whereas sodium fusidate was effective only for 3 weeks. Vancomycin and fosfomycin loaded into the hydroxyapatite composite had a significantly better inhibitive effect than when loaded in polymethylmethacrylate, whereas sodium fusidate loaded in polymethylmethacrylate showed a significantly better inhibitive effect than when loaded in the hydroxyapatite composite. Scanning electron microscopy and xray diffraction analysis elucidated the patterns of each drug release profile. The local hydroxyapatite composite is a promising local biodegradable delivery system for vancomycin and fosfomycin, whereas PMMA is a better carrier for sodium fusidate in treating methicillin-resistant staphylococcus aureus osteomyelitis.