An examination of the synergistic interaction of ethanol and thiamine deficiency in the development of neurological signs and long-term cognitive and memory impairments
An examination of the synergistic interaction of ethanol and thiamine deficiency in the development of neurological signs and long-term cognitive and memory impairments
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DOI：
10.1111/j.1530-0277.2000.tb02033.x
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发表时间：
2000-05-01
影响因子：
3.2
通讯作者：
Langlais, PJ
中科院分区：
文献类型：
--
作者：
Ciccia, RM;Langlais, PJ
背景资料：长期大量饮用乙醇与硫胺素缺乏和广泛的认知和记忆障碍有关。本研究旨在验证乙醇和硫胺素缺乏协同作用的假设，与单独的硫胺素缺乏或慢性乙醇相比，乙醇和硫胺素缺乏会产生更严重的临床神经障碍以及认知和记忆障碍。联合慢性脑梗死的急性神经和长期行为后果（32周）乙醇消耗量（20%v/v的饮用水）和三个单独的4周的膳食硫胺素缺乏（ET/TD）与单独的乙醇（ET）或硫胺素缺乏（TD）处理相比，在雄性Sprague道利（R）中进行了检查。结果：ET/TD组在每次硫胺素缺乏发作期间体重减轻少于TD组。与预期相反，ET/TD和TD组的共济失调、翻正反射受损和反强直姿势的进展和严重程度相似。治疗期间，ET动物均未显示任何神经或行为症状。在从乙醇中退出并经过7周的恢复期后，各组的自发活动均无差异。在随后的测试中，ET组在自发交替任务中表现出持续反应的显着增加。ET/TD（23%），ET（17%）和TD（8%）动物的一个小，但显着的比例无法达到标准的初始非匹配位置任务（NMTP）或在随后的两个逆转的匹配和NMTP任务，这表明持续的学习障碍。三组中的每一组中有很大比例的动物表现出显着降低的准确性相比，控制在较长的延迟匹配位置的任务（MTP），但只有ET组一贯受损，在较短的延迟。有没有显着的相关性血液乙醇浓度和任何的学习和记忆measurement.Conclusions：这些结果表明，慢性乙醇消耗和TD发作的相互作用是域特定的，并不总是协同。学习和参考记忆似乎是敏感的ET和TD的协同作用，而短期工作记忆障碍的ET和神经系统症状的影响是最相关的TD。此外，神经系统症状和血液乙醇浓度似乎都不是学习和记忆缺陷的良好预测因子。
Background: The prolonged and heavy consumption of ethanol has been associated with thiamine deficiency and a wide range of cognitive and memory impairments. The present study was undertaken to test the hypothesis that ethanol and thiamine deficiency act synergistically, producing more severe clinical neurological disturbances and cognitive and memory impairments than either thiamine deficiency or chronic ethanol alone.Methods: The acute neurological and long-term behavioral consequences of combined chronic (32 weeks) ethanol consumption (20% v/v in drinking water) and three separate 4-week long episodes of dietary thiamine deficiency (ET/TD) versus ethanol (ET) or thiamine deficiency (TD) treatments alone were examined in male Sprague Dawley(R) rats aged 12 weeks at the start of treatment.Results: The ET/TD group lost less weight than the TD group during each episode of thiamine deficiency. Contrary to expectations, the progression and severity of ataxia, impaired righting reflexes, and opisthotonic posturing were similar in the ET/TD, and TD groups. None of the ET animals displayed any neurological or behavioral symptoms during treatment. After withdrawal from ethanol and a 7-week recovery period, none of the groups differed in spontaneous activity. On subsequent testing, the ET group displayed a significant increase in perseverative responding in a spontaneous alternation task. A small but significant proportion of ET/TD (23%), ET (17%), and TD (8%) animals were unable to reach criterion on an initial nonmatching-to-position task (NMTP) or in two subsequent reversals of the matching and NMTP tasks, which indicated persistent learning impairments. A large proportion of animals in each of the three groups demonstrated significantly reduced accuracy compared with controls at longer delays of matching-to-position tasks (MTP), but only the ET group was consistently impaired at the shorter delays. There were no significant correlations between blood ethanol concentration and any of the learning and memory measures.Conclusions: These results indicate that the interaction of chronic ethanol consumption and bouts of TD is both domain specific and not always synergistic. Learning and reference memory appear to be sensitive to a synergistic interaction of ET and TD, whereas short-term working memory disturbances are most affected by ET and neurological symptoms are most associated with TD. Furthermore, neither the presence of neurological symptoms nor blood ethanol concentrations appear to be good predictors of learning and memory deficits.