Time-restricted feeding (TRF) for prevention of age-related vascular cognitive impairment and dementia.

Time-restricted feeding (TRF) for prevention of age-related vascular cognitive impairment and dementia.
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时间限制的喂养(TRF)用于预防与年龄有关的血管认知障碍和痴呆。

DOI:
10.1016/j.arr.2020.101189
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发表时间:
2020-12
影响因子:
13.1
通讯作者:
Tarantini S
Tarantini S
中科院分区:
医学1区
文献类型:
--
作者:
Balasubramanian P;DelFavero J;Ungvari A;Papp M;Tarantini A;Price N;de Cabo R;Tarantini S

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衰老是血管性认知障碍(VCI)最重要的危险因素,预计在未来几十年,血管性认知障碍患者的数量将呈指数级增长。然而,目前还没有预防或治疗方法可以预防VCI的发生和发展。因此,迫切需要更好地了解这些疾病的病理生理学基础,以便开发新的工具和干预措施来改善脑血管健康并延迟VCI的发生。有强有力的流行病学和实验证据表明,生活方式因素,包括营养和饮食习惯,显著影响脑血管健康,从而影响VCI的发病机制。在这里,最近的证据讨论了生活方式干预对年龄相关疾病的影响,这反过来又激发了新的研究,旨在调查饮食干预对预防老年人认知能力下降的可能有益影响。
Aging is the most significant risk factor for vascular cognitive impairment (VCI), and the number of individuals affected by VCI is expected to exponentially increase in the upcoming decades. Yet, there are no current preventative or therapeutic treatments available against the development and progression of VCI. Therefore, there is a pressing need to better understand the pathophysiology underlying these conditions, for the development of novel tools and interventions to improve cerebrovascular health and delay the onset of VCI. There is strong epidemiological and experimental evidence that lifestyle factors, including nutrition and dietary habits, significantly affect cerebrovascular health and thereby influence the pathogenesis of VCI. Here, recent evidence is presented discussing the effects of lifestyle interventions against age-related diseases which in turn, inspired novel research aimed at investigating the possible beneficial effects of dietary interventions for the prevention of cognitive decline in older adults.
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