Obesity-related pediatric asthma: relationships between pulmonary function and clinical outcomes.
Obesity-related pediatric asthma: relationships between pulmonary function and clinical outcomes.
复制标题
肥胖相关的小儿哮喘：肺功能与临床结果之间的关系。
DOI：
10.1080/02770903.2022.2152351
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Feldman,JonathanM
中科院分区：
文献类型：
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作者：
Starr,Sheena;Wysocki,Matthew;DeLeon,JesenyaD;Silverstein,Gabriella;Arcoleo,Kimberly;Rastogi,Deepa;Feldman,JonathanM
ObjectiveWe hypothesized that children with obesity-related asthma would have worse self-reported asthma control, report an increased number of asthma symptoms and have lower FEV1/FVC associated with worse clinical asthma outcomes compared to children with asthma only.MethodsCross sectional analyses examined two hundred and eighteen (obesity-related asthma = 109, asthma only = 109) children, ages 7–15 that were recruited from clinics and hospitals within the Bronx, NY. Pulmonary function was assessed by forced expiratory volume in the first second (percent predicted FEV1) and the ratio of FEV1to the forced vital capacity of the lungs (FEV1/FVC). Structural equation modeling examined if pulmonary function was associated with asthma control and clinical outcomes between groups.ResultsLower percent predicted FEV1was associated with increased hospitalizations (p= 0.03) and oral steroid bursts in the past 12 months (p= 0.03) in the obesity-related asthma group but not in the asthma only group. FEV1/FVC was also associated with increased hospitalizations (p= 0.02) and oral steroid bursts (p= 0.008) in the obesity-related asthma group but not the asthma only group. Lower FEV1/FVC was associated with the number of asthma symptoms endorsed in the asthma only group but not in the obesity-related asthma group. Percent predicted FEV1and FEV1/FVC was not associated with asthma control in either group.ConclusionsPulmonary function was associated with oral steroid bursts and hospitalizations but not self-reported asthma control, suggesting the importance of incorporating measures of pulmonary function into the treatment of pediatric obesity-related asthma.
