Contrasting effects of testosterone and stanozolol on serum lipoprotein levels.
Contrasting effects of testosterone and stanozolol on serum lipoprotein levels.
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DOI：
10.1001/jama.1989.03420080085036
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发表时间：
1989-02
期刊：
影响因子：
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通讯作者：
P. Thompson;E. Cullinane;S. Sady;C. Chenevert;A. Saritelli;Mina A. Sady;P. Herbert
中科院分区：
文献类型：
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作者：
P. Thompson;E. Cullinane;S. Sady;C. Chenevert;A. Saritelli;Mina A. Sady;P. Herbert
口服合成代谢类固醇可显著降低血清中高密度脂蛋白（HDL）胆固醇的浓度。我们假设这种作用与它们的给药途径有关，而与它们的雄性激素效力无关。我们给药口服康力龙（6毫克/天）或超生理剂量的肌肉注射庚酸睾酮（200毫克/周），以11名男性举重运动员六周的交叉设计。康力龙可使HDL-胆固醇和HDL 2亚组分分别降低33%和71%。相比之下，睾酮仅使HDL-胆固醇浓度降低9%，并且降低的是HDL 3亚组分。载脂蛋白A-I水平下降40%，司坦唑醇，但只有8%，在睾酮治疗。低密度脂蛋白胆固醇浓度增加29%，司坦唑醇和睾酮治疗下降16%。此外，司坦唑醇使肝素治疗后的肝甘油三酯脂肪酶活性增加123%，而睾酮治疗期间的最大变化（+25%）并不显著。两种药物的体重增加相似，但睾酮在抑制促性腺激素方面更有效。我们的结论是，17-α-烷基化类固醇口服给药的不良脂蛋白的影响是不同的胃肠外睾酮，后者在许多临床情况下可能是优选的。
Oral anabolic steroids produce striking reductions in serum concentrations of high-density lipoprotein (HDL) cholesterol. We hypothesized that this effect related to their route of administration and was unrelated to their androgenic potency. We administered oral stanozolol (6 mg/d) or supraphysiological doses of intramuscular testosterone enanthate (200 mg/wk) to 11 male weight lifters for six weeks in a crossover design. Stanozolol reduced HDL-cholesterol and the HDL2 subfraction by 33% and 71%, respectively. In contrast, testosterone decreased HDL-cholesterol concentration by only 9% and the decrease was in the HDL3 subfraction. Apolipoprotein A-I level decreased 40% during stanozolol but only 8% during testosterone treatment. The low-density lipoprotein cholesterol concentration increased 29% with stanozolol and decreased 16% with testosterone treatment. Stanozolol, moreover, increased postheparin hepatic triglyceride lipase activity by 123%, whereas the maximum change during testosterone therapy (+25%) was not significant. Weight gain was similar with both drugs, but testosterone was more effective in suppressing gonadotropic hormones. We conclude that the undesirable lipoprotein effects of 17-alpha-alkylated steroids given orally are different from those of parenteral testosterone and that the latter may be preferable in many clinical situations.