Hypoxia in astrocytic tumors and implications for therapy.
Hypoxia in astrocytic tumors and implications for therapy.
复制标题
DOI：
10.1016/j.nbd.2015.06.007
复制
发表时间：
2016-01
影响因子：
6.1
通讯作者：
Brenner AJ
中科院分区：
文献类型：
--
作者：
Cavazos DA;Brenner AJ
胶质母细胞瘤(GBM，IV级星形细胞瘤)是成人最常见、最具侵袭性的原发恶性脑肿瘤。缺氧是基底膜的一个明显特征，在肿瘤进展、耐药和不良预后中起着重要作用。本文综述了低氧对星形细胞肿瘤的影响以及导致肿瘤进展和耐药的机制，重点介绍了低氧引起的血管变化、趋化信号通路和代谢改变。
Glioblastoma (GBM, Grade IV astrocytoma) is the most common and most aggressive of the primary malignant brain tumors in adults. Hypoxia is a distinct feature in GBM and plays a significant role in tumor progression, resistance to treatment and poor outcomes. This review considers the effects of hypoxia on astrocytic tumors and the mechanisms that contribute to tumor progression and therapeutic resistance, with a focus on the vascular changes, chemotaxic signaling pathways and metabolic alterations involved.