Multiple functions of BCL-2 family proteins.
Multiple functions of BCL-2 family proteins.
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DOI：
10.1101/cshperspect.a008722
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发表时间：
2013-02-01
影响因子：
7.2
通讯作者：
Soane L
中科院分区：
文献类型：
--
作者：
Hardwick JM;Soane L
BCL-2家族蛋白是细胞凋亡的调节因子，但也具有其他功能。这个相互作用的伴侣家族包括细胞死亡的抑制剂和诱导剂。它们共同调节和介导线粒体导致细胞死亡的过程，称为内在凋亡途径。这一途径是正常胚胎发育和预防癌症所必需的。然而，在诱导凋亡之前，BCL-2蛋白在与神经元活性、自噬、钙处理、线粒体动力学和能量学以及正常健康细胞的其他过程相关的正常细胞生理学中具有关键作用。这些生理功能的相对重要性相比，它们的细胞凋亡功能在整个生物体生理学是很难破译。这些蛋白质的凋亡和非典型功能可能交织在一起，将细胞生长与细胞死亡联系起来。解开这些功能可能需要描绘的生化活动所固有的特征性的三维形状共享的远亲病毒和细胞BCL-2家族成员。
BCL-2 family proteins are the regulators of apoptosis, but also have other functions. This family of interacting partners includes inhibitors and inducers of cell death. Together they regulate and mediate the process by which mitochondria contribute to cell death known as the intrinsic apoptosis pathway. This pathway is required for normal embryonic development and for preventing cancer. However, before apoptosis is induced, BCL-2 proteins have critical roles in normal cell physiology related to neuronal activity, autophagy, calcium handling, mitochondrial dynamics and energetics, and other processes of normal healthy cells. The relative importance of these physiological functions compared to their apoptosis functions in overall organismal physiology is difficult to decipher. Apoptotic and noncanonical functions of these proteins may be intertwined to link cell growth to cell death. Disentanglement of these functions may require delineation of biochemical activities inherent to the characteristic three-dimensional shape shared by distantly related viral and cellular BCL-2 family members.
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