Higher liver fat content among Japanese in Japan compared with non-Hispanic whites in the United States
Higher liver fat content among Japanese in Japan compared with non-Hispanic whites in the United States
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DOI：
10.1016/j.metabol.2009.03.021
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发表时间：
2009-08-01
影响因子：
9.8
通讯作者：
Sekikawa, Akira
中科院分区：
文献类型：
--
作者：
Azuma, Koichiro;Kadowaki, Takashi;Sekikawa, Akira
在亚洲人中，包括日本人，肥胖与血脂异常和胰岛素抵抗有关，与非西班牙裔白人（NHW）相比，体重指数（BMI）水平较低。我们假设BMI和代谢风险之间关系的种族差异部分与脂肪分布的种族差异有关，即肝脏脂肪和内脏脂肪组织。为了比较日本与NHW男性之间的肝脏脂肪含量，区域计算机断层扫描图像，以测量肝脏计算机断层扫描密度在人口为基础的样本3 13日本和288 NHW男性年龄在40至49岁，沿着与代谢参数的评估。日本男性的肝脏脂肪含量高于NHW男性（肝脏与脾脏的衰减比[数值越低意味着肝脏脂肪含量越高]：分别为1.01 +/- 0.16 vs 1.07 +/- 0.15; P
Among Asians, including Japanese, obesity is related to dyslipidemia and insulin resistance at a lower level of body mass index (BMI) compared with non-Hispanic whites (NHW). We hypothesize that this ethnic difference in the relationship between BMI and metabolic risks is partly associated with the ethnic difference in fat distribution, namely, liver fat as well as visceral adipose tissue. To compare liver fat content among Japanese vs NHW men, regional computed tomographic images were taken to measure liver computed tomographic density in population-based samples of 3 13 Japanese and 288 NHW men aged 40 to 49 years, along with the assessment of metabolic parameters. Liver fat content was higher in Japanese than NHW men (liver to spleen attenuation ratio [lower value means higher liver fat content]: 1.01 +/- 0.16 vs 1.07 +/- 0.15, respectively; P