Triglyceride Glucose Index Predicting Cardiovascular Mortality in Chinese Initiating Peritoneal Dialysis: A Cohort Study
Triglyceride Glucose Index Predicting Cardiovascular Mortality in Chinese Initiating Peritoneal Dialysis: A Cohort Study
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甘油三酯葡萄糖指数预测中国人开始腹膜透析的心血管死亡率：一项队列研究
DOI：
10.1159/000500979
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发表时间：
2019-01-01
影响因子：
2.8
通讯作者：
Simmons, David
中科院分区：
文献类型：
--
作者：
Yan, Zechen;Yu, Dahai;Simmons, David
背景：终末期肾病（ESRD）患者的胰岛素抵抗（IR）增加。甘油三酯葡萄糖 (TyG) 指数是 IR 的标志物，也与开始腹膜透析 (PD) 患者的心血管疾病预后相关。本研究旨在探讨 PD 患者 TyG 指数与心血管死亡之间的关联。方法和结果：来自河南省PD登记处的前瞻性队列纳入了2007年至2014年间354名开始PD的患者，测量了ESRD患者开始PD时的TyG指数以及其他基线特征。调整年龄、性别和主要心血管危险因素的逻辑回归估计了 TyG 指数与 PD 开始后 2 年内随后的心血管死亡率之间的关联。结果：TyG 指数与心血管死亡率呈正相关：比较最高与最低 TyG 指数四分位的调整后发病率比 (95% CI) 为 2.32 (2.12–2.55)，体重指数 (BMI) <25 kg/m2 的患者为 2.22 (2.01–2.46)，BMI ≥ 25 的患者为 2.82 (2.24–3.54)分别为千克/平方米。 BMI 揭示了线性剂量反应关系。结论：TyG 指数可能是预测 PD 患者心血管死亡率的预后因素。
Background: Insulin resistance (IR) is increased among people with end-stage renal disease (ESRD). The Triglyceride glucose (TyG) index is a marker of IR and is also associated with the prognosis of cardiovascular disease among patients initiating peritoneal dialysis (PD). This study was aimed at examining the associations between TyG index and cardiovascular deaths in patients initiating PD. Methods and Results: Three thousand fifty-four patients initiating PD between 2007 and 2014 were included in a prospective cohort derived from Henan PD Registry, TyG index alongside other baseline characteristics were measured when ESRD patients initiated PD. Logistic regression adjusting for age, gender, and major cardiovascular risk factors estimated the association between TyG index and subsequent cardiovascular mortality within 2 years since the initiation of PD. Results: TyG index was positively associated with cardiovascular mortality: adjusted incidence rates ratio (95% CI) comparing the highest vs. lowest TyG index quartile was 2.32 (2.12–2.55) in all, 2.22 (2.01–2.46) in those with body mass index (BMI) <25 kg/m2, and 2.82 (2.24–3.54) in those with BMI ≥25 kg/m2, respectively. Linear dose-response relationships were revealed in all and by BMI. Conclusions: TyG index might be a prognostic factor in predicting cardiovascular mortality among patients initiating PD.