RENEWAL OF SPERMATOGONIA IN THE RAT
RENEWAL OF SPERMATOGONIA IN THE RAT
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DOI：
10.1002/aja.1000930308
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发表时间：
1953-01-01
影响因子：
--
通讯作者：
LEBLOND, CP
中科院分区：
文献类型：
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作者：
CLERMONT, Y;LEBLOND, CP
通过对大鼠生精上皮细胞14个阶段中每一个阶段的精原细胞(A型、中间型和B型)的计数，揭示了精原细胞的更新模式。精原细胞有丝分裂发生在周期的早期(阶段I)，产生特殊的A型精原细胞，在这里被称为“休眠”，因为它们在周期的前8个阶段不分裂。在第IX期，每个休眠细胞产生2个A型精原细胞，这些精原细胞继而分裂，尽管不是同时分裂。在下一个周期开始时(第一阶段)从这些分裂中产生的4个细胞中，有1个仍然是休眠的A型精原细胞，最终将提供下一代细胞；另外3个细胞立即分裂产生6个A型细胞，逐渐转变为中间型细胞。到第四阶段，这些精原细胞分裂产生12个B型精原细胞，在第六阶段分裂产生24个年轻的精母细胞。在老鼠和其他物种中。同样，这一过程也是描述的，即当其他精原细胞分裂产生精母细胞时，休眠的精原细胞周期性地出现。作为干细胞更新理论。这一过程允许精母细胞的循环形成以及精原细胞种群的维持。
By enumeration of the spermatogonia (types A, intermediate, and B) present at each of the 14 stages of the cylce of the seminiferous epithelium of the rat, the pattern of renewal of the spermatogonia was revealed. Spermatogonial mitoses occurring early in the cycle (stage I) give rise to special spermatogonia of type A, which here are designated "dormant" since they do not divide during the 1st 8 stages of the cycle. At stage IX, each dormant cell gives rise to 2 type A spermatogonia which in turn divide, although not simultaneously. Of the 4 cells which have arisen from these divisions by the beginning (stage I) of the next cycle, 1 again, remains as a dormant type A spermatogonium which will eventually provide the cells of the next generation; the 3 others divide immediately to produce 6 type A cells, which gradually transform into intermediate type cells. By stage IV, these divide to produce 12 type B spermatogonia, which at stage VI divide to give rise to 24 young spermatocytes. In rats and other spp. as well, this process, that is the periodic appearance of a dormant spermatogonium while other spermatogonia divide to produce spermatocytes, is descr. as the Stem Cell Renewal Theory. This process allows for the cyclic formation of spermatocytes as well as the maintenance of the spermatogonial population.