The relationship between subchondral sclerosis detected with MRI and cartilage loss in a cohort of subjects with knee pain: the knee osteoarthritis progression (KOAP) study
The relationship between subchondral sclerosis detected with MRI and cartilage loss in a cohort of subjects with knee pain: the knee osteoarthritis progression (KOAP) study
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DOI：
10.1016/j.joca.2014.01.006
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发表时间：
2014-04-01
影响因子：
7
通讯作者：
Guermazi, A.
中科院分区：
文献类型：
--
作者：
Crema, M. D.;Cibere, J.;Guermazi, A.
目的：在一组膝关节疼痛患者中，评估基线MRI检测到的软骨下硬化症与膝关节同一区域随时间推移的软骨丢失之间的关系。方法：163名膝关节疼痛患者参加了一项纵向研究，以评估膝关节骨关节炎进展(KOAP)。受试者接受了基线的膝关节X线片以及基线和3年的随访MRI检查。基线软骨下硬化症和骨髓病变(BMLS)在MRI上的评分范围为0~3分，软骨形态评分为0~4分。采用Logistic回归分析，调整年龄、性别、体重指数和伴发BML的结果，评估基线软骨下硬化症与膝关节同一区域软骨丢失的相关性。结果：MRI检测膝关节软骨下硬化症的患病率介于1.6%(滑车)和17%(胫骨内侧)之间。随着时间的推移，软骨丢失的发生率从6%(胫骨外侧)到13.1%(股骨内侧)不等。骨间隔内放射学检测到的软骨下硬化症的发生率从2.9%(髌股关节)到14.2%(胫股内侧)不等。在Logistic回归模型中，MRI检测到的基线软骨下硬化与膝关节同一区域的软骨丢失之间没有显著的相关性。结论：MRI检测到的基线软骨下硬化不会随着时间的推移增加软骨丢失的风险。(C)2014国际骨性关节炎研究会。爱思唯尔有限公司出版。保留所有权利。
Purpose: To assess the association between subchondral sclerosis detected at baseline with MRI and cartilage loss over time in the same region of the knee in a cohort of subjects with knee pain.Methods: 163 subjects with knee pain participated in a longitudinal study to assess knee osteoarthritis progression (KOAP). Subjects received baseline knee radiographs as well as baseline and 3-year follow-up MRI examinations. Baseline subchondral sclerosis and bone marrow lesions (BMLs) were scored semiquantitatively on MRI in each region from 0 to 3. Cartilage morphology at baseline and follow-up was scored semiquantitatively from 0 to 4. The association between baseline subchondral sclerosis and cartilage loss in the same region of the knee was evaluated using logistic regression, adjusting the results for age, gender, body mass index, and the presence of concomitant BMLs.Results: The prevalence of subchondral sclerosis detected by MRI in the regions of the knee varied between 1.6% (trochlea) and 17% (medial tibia). The occurrence of cartilage loss over time in regions varied between 6% (lateral tibia) and 13.1% (medial femur). The prevalence of radiographically-detected subchondral sclerosis in compartments varied from 2.9% (patellofemoral) to 14.2% (medial tibiofemoral). In logistic regression models, there were no significant associations between baseline subchondral sclerosis detected by MRI and cartilage loss in the same region of the knee.Conclusion: Baseline subchondral sclerosis as detected by MRI did not increase the risk of cartilage loss over time. (C) 2014 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.