RNA pseudouridylation: new insights into an old modification.
RNA pseudouridylation: new insights into an old modification.
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RNA 假尿苷化：对旧修饰的新见解。
DOI：
10.1016/j.tibs.2013.01.002
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发表时间：
2013-04
影响因子：
13.8
通讯作者：
Yu, Yi-Tao
中科院分区：
文献类型：
--
作者：
Ge, Junhui;Yu, Yi-Tao
假尿嘧啶是所有生物各种稳定rna中最丰富的转录后修饰核苷酸。假尿嘧啶是通过碱基特异性异构化从尿嘧啶衍生而来，产生一个额外的氢键供体，使其与其他核苷酸区别开来。在真核生物中，尿嘧啶到假尿嘧啶的异构化主要由box H/ACA RNPs催化，这些核糖核蛋白充当假尿嘧啶酶。当引入RNA时，假尿嘧啶对RNA介导的细胞过程有显著贡献。最近发现应激可诱导假尿嘧啶化，提示假尿嘧啶具有调节作用。也有报道称，假尿嘧啶可以通过box H/ACA RNPs人工导入mRNA，并且这种引入可以介导无义到义密码子的转换，从而展示了一种产生编码/蛋白质多样性的新手段。
Pseudouridine is the most abundant posttranscriptionally modified nucleotide in various stable RNAs of all organisms. Pseudouridine is derived from uridine via base-specific isomerization, resulting in an extra hydrogen bond donor that distinguishes it from other nucleotides. In eukaryotes, uridine-to-pseudouridine isomerization is catalyzed primarily by box H/ACA RNPs, ribonucleoproteins that act as pseudouridylases. When introduced into RNA, pseudouridine contributes significantly to RNA-mediated cellular processes. It was recently discovered that pseudouridylation can be induced by stress, suggesting a regulatory role for pseudouridine. It has also been reported that pseudouridine can be artificially introduced into mRNA by box H/ACA RNPs and that such introduction can mediate nonsense-to-sense codon conversion, thus demonstrating a new means of generating coding/protein diversity.
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