A Genetically Encoded Indicator for Monitoring Intracellular Chloride
A Genetically Encoded Indicator for Monitoring Intracellular Chloride
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DOI：
10.1007/s11062-007-0047-0
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发表时间：
2007-07-01
期刊：
影响因子：
0.5
通讯作者：
Bregestovski, P.
中科院分区：
文献类型：
--
作者：
Markova, O.;Real, E.;Bregestovski, P.
神经系统中的抑制性驱动是由突触提供的，突触主要通过氯离子通道工作。我们描述了一种基于CFP-YFP的新型荧光氯离子指示剂，氯离子传感器，具有高灵敏度的特点，可以成功地作为一种工具用于监测各种生物制剂中的细胞内氯离子。
Inhibitory drives in the nervous system are provided by synapses operating mostly through Cl- ion channels. We describe a novel CFP-YFP-based fluorescence Cl- indicator, Cl-sensor, characterized by a high sensitivity, which can be successfully used as a tool for monitoring intracellular Cl- in various biological preparations.