Smoothened Regulation: A Tale of Two Signals.
Smoothened Regulation: A Tale of Two Signals.
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DOI：
10.1016/j.tips.2015.09.001
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发表时间：
2016-01
影响因子：
13.8
通讯作者：
Ogden SK
中科院分区：
文献类型：
--
作者：
Arensdorf AM;Marada S;Ogden SK
G蛋白偶联受体Smoothened（Smo）是发育和治疗相关的Hedgehog通路的信号转导子。虽然最近的结构分析已经推进了我们对Smo生物学的理解，但仍然存在一些问题。其中主要是其天然配体的身份，控制其激活的调节过程，以及它向下游效应器发出信号的机制。这篇评论将讨论最近发现的多个模型系统，为解决这些谜团奠定了基础。我们专注于不同的Smo功能结构域，翻译后修饰和贩运的作用，并通过讨论其对信号输出的贡献得出结论。
The G protein-coupled receptor Smoothened (Smo) is the signal transducer of the developmentally- and therapeutically-relevant Hedgehog pathway. Although recent structural analyses have advanced our understanding of Smo biology, a number of questions remain. Chief among them are the identity of its natural ligand, the regulatory processes controlling its activation, and the mechanisms by which it signals to downstream effectors. This review will discuss recent discoveries from multiple model systems that have set the stage for solving these mysteries. We focus on the roles of distinct Smo functional domains, post-translational modifications and trafficking, and conclude by discussing their contributions to signal output.