Noninvasive Imaging of Aortic Atherosclerosis by Ultrasound Biomicroscopy in a Mouse Model
Noninvasive Imaging of Aortic Atherosclerosis by Ultrasound Biomicroscopy in a Mouse Model
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在小鼠模型中通过超声生物显微镜对主动脉粥样硬化进行无创成像
DOI：
10.7863/ultra.34.1.111
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发表时间：
2015-01-01
影响因子：
2.3
通讯作者：
Yang, Ya
中科院分区：
文献类型：
--
作者：
Zhang, Xiaoshan;Ha, Si;Yang, Ya
目的无创、准确地评价小鼠血管模型的特性已成为血管医学研究的热点。本研究旨在应用超声生物显微镜评价低密度脂蛋白受体（LDL-R）基因敲除小鼠动脉粥样硬化（AS）模型的主动脉粥样硬化进展。方法10只16周龄和24周龄的雄性LDL-R-/-CS 7 BL/6小鼠和8只16周龄和24周龄的雄性野生型C57 BL/6小鼠分别作为实验组和对照组。应用超声生物显微镜观察主动脉根部、升主动脉、主动脉弓、结果超声生物显微镜显示主动脉根部内膜-中层厚度从16周龄小鼠的0.10 ± 0.03 mm增加到0.16 ± 0.03 mm，0.04 mm（P
Objectives The noninvasive and accurate evaluation of vessel characteristics in mouse models has become an intensive focus of vascular medicine. This study aimed to apply ultrasound biomicroscopy to evaluate aortic atherosclerotic progression in a low-density lipoprotein receptor (LDL-R) knockout mouse model of atherosclerosis.Methods Ten male LDL-R-/- CS7BL/6 mice aged 16 and 24 weeks and 8 male wildtype C57BL/6 mice aged 16 and 24 weeks were used as experimental and control groups, respectively. Ultrasound biomicroscopy was applied to detect the morphologic characteristics of the aortic root, ascending aorta, aortic arch, and carotid artery and to measure the aortic root intima-media thickness and carotid artery bifurcation.Results Ultrasound biomicroscopy showed a significant increase in the aortic root intima-media thickness from 0.10 +/- 0.03 mm in 16-week-old mice to 0.16 +/- 0.04 mm in 24-week-old mice (P