Alternative splicing as a regulator of development and tissue identity.
Alternative splicing as a regulator of development and tissue identity.
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DOI：
10.1038/nrm.2017.27
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Giudice J
中科院分区：
文献类型：
--
作者：
Baralle FE;Giudice J
真核转录本的选择性剪接是一种机制，它显著有助于从相当有限的基因中产生巨大的蛋白质多样性。人们相对较好地了解了单个转录本的选择性剪接的机制和结果，最近的努力集中在研究剪接网络上。很明显，协调的剪接网络调节组织和器官的发育，而选择性剪接在人类不同的发育过程中具有重要的生理功能。选择性剪接通过从单个基因产生多个转录物(和蛋白质)亚型来扩大蛋白质组的复杂性。在细胞分化和组织成熟过程中发生了大量的选择性剪接事件，表明选择性剪接支持适当的发育。最近的研究揭示了选择性剪接及其协调如何调节器官发育和组织动态平衡。
Alternative splicing of eukaryotic transcripts is a mechanism that significantly contributes to the generation of the vast protein diversity from a rather limited number of genes. The mechanisms and outcomes of alternative splicing of individual transcripts are relatively well understood, and recent efforts have been directed towards studying splicing networks. It has become apparent that coordinated splicing networks regulate tissue and organ development, and that alternative splicing has important physiological functions in different developmental processes in humans. Alternative splicing expands proteome complexity by generating multiple transcript (and protein) isoforms from a single gene. Numerous alternative splicing events occur during cell differentiation and tissue maturation, suggesting that alternative splicing supports proper development. Recent studies shed light on how alternative splicing and its coordination regulates organ development and tissue homeostasis.
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影响因子：
11.8
作者：
Carreira-Rosario A;Bhargava V;Hillebrand J;Kollipara RK;Ramaswami M;Buszczak M
通讯作者：
Buszczak M
DOI：
10.1007/978-1-4939-1221-6_8
发表时间：
2014-01-01
期刊：
SYSTEMS BIOLOGY OF RNA BINDING PROTEINS
影响因子：
--
作者：
Bebee, Thomas W.;Cieply, Benjamin W.;Carstens, Russ P.
通讯作者：
Carstens, Russ P.
影响因子：
10.8
作者：
Beqqali, Abdelaziz;Bollen, Ilse A. E.;Pinto, Yigal M.
通讯作者：
Pinto, Yigal M.
影响因子：
4.8
作者：
Beffert, U;Morfini, G;Herz, J
通讯作者：
Herz, J
影响因子：
3.5
作者：
Beraldi, Rosanna;Li, Xing;Nelson, Timothy J.
通讯作者：
Nelson, Timothy J.