Repeated administration of antidepressant drugs reduces regional somatostatin concentrations in rat brain.
Repeated administration of antidepressant drugs reduces regional somatostatin concentrations in rat brain.
复制标题
重复施用抗抑郁药物会降低大鼠大脑中局部生长抑素的浓度。
DOI：
10.1016/0165-0327(92)90078-k
复制
发表时间：
1992
影响因子：
6.6
通讯作者：
K. Chihara
中科院分区：
文献类型：
--
作者：
T. Kakigi;K. Maeda;H. Kaneda;K. Chihara
抑郁症患者脑脊液中生长抑素浓度较低，提示生长抑素在情感性精神障碍中可能发挥作用。因此，我们研究了抗抑郁药物和抗躁狂药对大鼠脑内生长抑素浓度的区域性影响。反复但不是急性地给予氯丙咪嗪，一种特定的5-羟色胺摄取抑制剂，导致生长抑素水平非常显著的广泛下降。反复服用另一种特定的5-羟色胺摄取抑制剂齐美利定后，下丘脑、中脑和丘脑中的生长抑素含量也同样减少。反复服用丙咪嗪、马普替林、米安色林、卡马西平或佐特平对生长抑素水平无影响。这些结果表明，大脑中的生长抑素可能参与了一些抗抑郁药物的治疗效果。
A possible role for somatostatin in affective disorders is suggested by its low concentration in cerebrospinal fluid of patients with depression. Therefore, we studied the regional effects of antidepressant drugs and antimanic agents on somatostatin concentrations in rat brain. Repeated, but not acute, administration of clomipramine, a specific serotonin uptake inhibitor, caused a highly significant, widespread reduction in somatostatin levels. Somatostatin content was similarly reduced in the hypothalamus, and midbrain and thalamus following repeated administration of zimelidine, another specific serotonin uptake inhibitor. Repeated administration of either imipramine, maprotiline, mianserin, carbamazepine or zotepine were without effect on somatostatin levels. These results suggest that somatostatin in the brain might be involved in therapeutic effects of some of antidepressant drugs.
影响因子：
--
作者：
D. Charney;D. Menkes;G. Heninger
通讯作者：
D. Charney;D. Menkes;G. Heninger
单胺代谢物、促肾上腺皮质激素释放因子和生长抑素作为抑郁症患者的脑脊液标志物。
影响因子：
6.6
作者：
Widerlöv,E;Bissette,G;Nemeroff,CB
通讯作者：
Nemeroff,CB
长期抗抑郁药治疗会降低螺哌啶醇标记的血清素受体结合。
DOI：
10.1126/science.6251550
发表时间：
1980
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Peroutka,SJ;Snyder,SH
通讯作者：
Snyder,SH