STABLE ISOTOPES IN PHARMACOLOGY STUDIES - PRESENT AND FUTURE
STABLE ISOTOPES IN PHARMACOLOGY STUDIES - PRESENT AND FUTURE
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DOI：
10.1002/j.1552-4604.1986.tb03563.x
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发表时间：
1986-07-01
影响因子：
2.9
通讯作者：
BROWNE, TR
中科院分区：
文献类型：
--
作者：
BROWNE, TR
与旧方法相比，稳定同位素技术在安全性、灵敏度、特异性、减少某些类型药理学研究所需受试者数量和分析测定方面具有优势。除了用作气相色谱-质谱分析方法中的内标外，稳定同位素还成功地应用于吸收、生物利用度、分布、生物转化、排泄、代谢物鉴定、时间依赖性和剂量依赖性药代动力学变化、药物相互作用、妊娠期间的药理变化、致突变性和致畸性的研究。
Stable‐isotope techniques offer advantages over older methods in safety, sensitivity, specificity, and reduction in numbers of subjects required and analytic determinations for some types of pharmacology studies. In addition to their use as internal standards in gas chromatography‐mass spectrometry analytic methods, stable isotopes have been successfully employed in studies of absorption, bioavailability, distribution, biotransformation, excretion, metabolite identification, time‐dependent and dose‐dependent pharmacokinetic changes, drug interactions, pharmacologic changes during pregnancy, mutagenicity, and teratogenicity.