AN ECOLOGICAL STUDY OF THE RELATIONSHIP BETWEEN DIETARY-FAT INTAKE AND BREAST-CANCER MORTALITY
AN ECOLOGICAL STUDY OF THE RELATIONSHIP BETWEEN DIETARY-FAT INTAKE AND BREAST-CANCER MORTALITY
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DOI：
10.1006/pmed.1993.1016
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发表时间：
1993-03-01
影响因子：
5.1
通讯作者：
KESTELOOT, H
中科院分区：
文献类型：
--
作者：
SASAKI, S;HORACSEK, M;KESTELOOT, H
方法.利用30个国家1961 ~ 1986年的数据，对联合国粮农组织食物平衡表中动物脂肪、植物脂肪和鱼类脂肪的人均供应量与女性乳腺癌死亡率之间的关系进行了生态学研究。在单变量分析中，发现50岁及以上年龄组的乳腺癌死亡率与动物脂肪减去鱼类脂肪摄入量之间的最高相关性存在约10年的滞后期。50岁及以上的年龄组显示脂肪摄入量与乳腺癌死亡率之间的相关性高于50岁以下的年龄组。多元回归分析显示，动物脂肪减去鱼类脂肪的摄入量与50岁及以上年龄组的乳腺癌死亡率呈极显著正相关（P< 0.001）。当显著时，膳食鱼脂肪摄入量与乳腺癌死亡率呈负相关（P< 0.001），植物脂肪摄入量与乳腺癌死亡率呈正相关（P< 0.01）。此外，动物脂肪减去鱼类脂肪摄入量随时间的变化与乳腺癌死亡率之间存在显着的正相关关系（P< 0.001）。为了证实这些发现，我们还研究了乳腺癌死亡率与脂肪摄入量之间的相关性，这些数据来自17个国家进行的46项饮食调查。尽管这些结果的重要性稍低，但它们证实了使用粮农组织数据得出的关系。我们的研究结果证实了膳食脂肪与乳腺癌单态性之间的高度显着正相关。效果根据消耗的脂肪类型而不同。
Methods. An ecologic study of the relationship between the per person supply of animal fat, vegetable fat, and fish fat obtained from the Food and Agricultural Organizations of the United Nations food balance sheets and female breast cancer mortality rates from 1961 to 1986 was carried out using data from 30 countries.Results. In univariate analysis, a lag period of about 10 years was found for the highest correlations between breast cancer mortality rates and animal fat minus fish fat intake in the age groups 50 years and above. Age classes 50 years and above showed higher correlations between fat intake and breast cancer mortality than those below 50 years over the periods examined. In multiple regression analysis, animal fat minus fish fat intake showed a highly significant positive relationship with the breast cancer mortality rates (P< 0.001) in age groups 50 years and above for all the periods examined. Whenever significant, dietary fish fat intake correlated negatively (P< 0.001) and vegetable fat positively (P< 0.01) with breast cancer mortality. Moreover, a significant positive relationship (P< 0.001) between the change over time in animal fat minus fish fat intake and that in breast cancer mortality was found. To confirm these findings we also examined the correlation between breast cancer mortality and fat consumption data obtained from 46 dietary surveys performed in 17 countries.Conclusions. Although slightly less significant, the findings corroborate the relationships obtained by using FAO data. Our findings confirm the highly significant positive association between dietary fat and breast cancer monality. The effect differs according to the type of fat consumed.