Epigenetic control of germline development.
Epigenetic control of germline development.
复制标题
DOI：
10.1007/978-1-4614-4015-4_13
复制
发表时间：
2013
影响因子：
--
通讯作者：
Priscilla M. Van Wynsberghe;E. M. Maine
中科院分区：
文献类型：
--
作者：
Priscilla M. Van Wynsberghe;E. M. Maine
组蛋白修饰和小的非编码RNA的动态调节在整个C.优雅的生殖线。组蛋白修饰在有丝分裂与减数分裂生殖系、X染色体与常染色体以及配对染色体与未配对染色体中受到差异调节。小RNA在转座子沉默和发育基因调节中发挥作用。生殖系中产生的组蛋白修饰和小RNA可以遗传并影响胚胎发育。生殖系中组蛋白修饰酶或小RNA机制的破坏可导致由于生殖系变性和/或不能产生功能性配子而导致的不育。
Dynamic regulation of histone modifications and small noncoding RNAs is observed throughout the development of theC. elegansgerm line. Histone modifications are differentially regulated in the mitotic vs meiotic germ line, on X chromosomes vs autosomes and on paired chromosomes vs unpaired chromosomes. Small RNAs function in transposon silencing and developmental gene regulation. Histone modifications and small RNAs produced in the germ line can be inherited and impact embryonic development. Disruption of histone-modifying enzymes or small RNA machinery in the germ line can result in sterility due to degeneration of the germ line and/or an inability to produce functional gametes.