Molecular Pathways Molecular Pathways : Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy
Molecular Pathways Molecular Pathways : Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy
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发表时间：
2013
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通讯作者：
V. Nogueira;N. Hay
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作者：
V. Nogueira;N. Hay
活性氧（ROS）在调节正常细胞过程中是重要的，但失调的ROS有助于各种人类疾病的发展，包括癌症。与正常细胞相比，癌细胞具有增加的ROS水平，因为它们的加速代谢。癌细胞中的高活性氧水平，使它们区别于正常细胞，可能是促肿瘤的，但也是它们的致命弱点。癌细胞中的高ROS含量使它们更容易受到氧化应激诱导的细胞死亡的影响，并且可以用于选择性癌症治疗。在这篇综述中，我们描述了几种潜在的治疗策略，这些策略通过进一步增加氧化应激，单独或与调节某些信号通路的药物联合，利用癌细胞中ROS的不平衡。临床癌症研究; 19（16）; 4309-14。2013年AACR。
Reactive oxygen species (ROS) are important in regulating normal cellular processes, but deregulated ROS contribute to the development of various human diseases, including cancers. Cancer cells have increased ROS levels compared with normal cells, because of their accelerated metabolism. The high ROS levels in cancer cells, which distinguish them fromnormal cells, could be protumorigenic, but are also their Achilles’ heel. The high ROS content in cancer cells renders them more susceptible to oxidative stress–induced cell death, and can be exploited for selective cancer therapy. In this review, we describe several potential therapeutic strategies that take advantage of ROS imbalance in cancer cells by further increasing oxidative stress, either alone or in combination with drugs that modulate certain signaling pathways. Clin Cancer Res; 19(16); 4309–14. 2013 AACR.