Amino Acids As Mediators of Metabolic Cross Talk between Host and Pathogen.
Amino Acids As Mediators of Metabolic Cross Talk between Host and Pathogen.
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DOI：
10.3389/fimmu.2018.00319
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发表时间：
2018
影响因子：
7.3
通讯作者：
Yin Y
中科院分区：
文献类型：
--
作者：
Ren W;Rajendran R;Zhao Y;Tan B;Wu G;Bazer FW;Zhu G;Peng Y;Huang X;Deng J;Yin Y
宿主和病原体之间的相互作用决定性地塑造了感染的结果，因此理解这种相互作用对于治疗病原体诱导的感染至关重要。虽然在细胞生物学的这一领域的研究已经取得了令人惊讶的发现宿主和病原体之间的相互作用，宿主和病原体之间的代谢串扰的理解是有限的。在感染部位，宿主和病原体共享相似或相同的营养底物并产生共同的代谢产物，因此宿主和病原体之间的代谢串扰可以深刻地影响感染的发病机制。在这篇综述中，我们提出的结果，最近发现的宿主和病原体之间的代谢相互作用的氨基酸（AA）代谢为中心的观点。宿主依赖AA代谢来支持对病原体的防御反应，而病原体调节AA代谢以获得自身优势。一些氨基酸，如精氨酸、天冬酰胺和色氨酸，是宿主和病原体之间竞争的中心点。因此，更好地了解AA介导的宿主和病原体之间的代谢串扰将提供深入了解富有成效的治疗方法，以操纵和预防感染的进展。
The interaction between host and pathogen decidedly shapes the outcome of an infection, thus understanding this interaction is critical to the treatment of a pathogen-induced infection. Although research in this area of cell biology has yielded surprising findings regarding interactions between host and pathogen, understanding of the metabolic cross talk between host and pathogen is limited. At the site of infection, host and pathogen share similar or identical nutritional substrates and generate common metabolic products, thus metabolic cross talk between host and pathogen could profoundly affect the pathogenesis of an infection. In this review, we present results of a recent discovery of a metabolic interaction between host and pathogen from an amino acid (AA) metabolism-centric point of view. The host depends on AA metabolism to support defensive responses against pathogens, while the pathogens modulate AA metabolism for its own advantage. Some AA, such as arginine, asparagine, and tryptophan, are central points of competition between the host and pathogen. Thus, a better understanding of AA-mediated metabolic cross talk between host and pathogen will provide insight into fruitful therapeutic approaches to manipulate and prevent progression of an infection.