Multiparametric estimation of brain hemodynamics with MR fingerprinting ASL.
Multiparametric estimation of brain hemodynamics with MR fingerprinting ASL.
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DOI：
10.1002/mrm.26587
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发表时间：
2017-11
影响因子：
3.3
通讯作者：
Lu H
中科院分区：
文献类型：
--
作者：
Su P;Mao D;Liu P;Li Y;Pinho MC;Welch BG;Lu H
无外源性造影剂的脑血流动力学评价在临床应用中越来越重要。本研究旨在开发一种MR灌注技术，可以提供非对比和多参数估计的血流动力学标志物。我们设计了一种基于MR指纹（MRF）原理的动脉自旋标记（ASL）方法，简称MRF-ASL。通过利用MRF序列中包含的丰富信息，可以同时估计多达7个血流动力学参数。进行了可行性论证、翻转角优化、与Look-Doppler ASL的比较、再现性试验、对高碳酸血症挑战的敏感性以及在颅内狭窄闭塞过程Moyamoya病中的初步临床应用，以评价该技术。MRF-ASL可估计多达7个参数，包括B1+、组织T1、脑血流量（CBF）、组织团注到达时间（BAT）、通过动脉BAT、通过血容量和通过血液行程时间。估计参数的变异系数（CoV）范围为0.2%至9.6%。高碳酸血症导致组织和血管中CBF增加57.7%，BAT分别减少13.7%和24.8%。烟雾病患者表现出CBF减少和BAT延长，这是常规ASL无法检测到的。MRF-ASL是一种很有前途的非造影剂、多参数灌注评估技术。
Assessment of brain hemodynamics without exogenous contrast agents is of increasing importance in clinical applications. This study aims to develop an MR perfusion technique that can provide non-contrast and multi-parametric estimation of hemodynamic markers. We devised an Arterial-Spin-Labeling (ASL) method based on the principle of MR Fingerprinting (MRF), referred to as MRF-ASL. By taking advantage of the rich information contained in MRF sequence, up to seven hemodynamic parameters can be estimated concomitantly. Feasibility demonstration, flip angle optimization, comparison with Look-Locker ASL, reproducibility test, sensitivity to hypercapnia challenge, and initial clinical application in an intracranial steno-occlusive process, Moyamoya disease, were performed to evaluate this technique. MRF-ASL provided estimation of up to seven parameters, including B1+, tissue T1, cerebral blood flow (CBF), tissue bolus-arrival-time (BAT), pass-through arterial BAT, pass-through blood volume, and pass-through blood travel time. Coefficients-of-variation (CoV) of the estimated parameters ranged from 0.2% to 9.6%. Hypercapnia resulted in an increase in CBF by 57.7%, and a decrease in BAT by 13.7% and 24.8% in tissue and vessels, respectively. Patients with Moyamoya disease showed diminished CBF and lengthened BAT that could not be detected with regular ASL. MRF-ASL is a promising technique for non-contrast, multi-parametric perfusion assessment.