Effectiveness of a home-based exercise intervention for HIV-infected adults: a randomized trial.
Effectiveness of a home-based exercise intervention for HIV-infected adults: a randomized trial.
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DOI：
10.1016/s1055-3290(06)60199-4
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发表时间：
2002-03-01
期刊：
影响因子：
--
通讯作者：
Wu, Albert W
中科院分区：
文献类型：
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作者：
Baigis, Judith;Korniewicz, Denise M;Wu, Albert W
作者进行了一项随机对照试验，以评估为期15周(每周3次，每次20分钟)的家庭有氧运动干预与常规护理对99名HIV感染成年人的身体耐力、免疫状况和自我报告的健康状况的影响。在运动组，除了医学结果研究-艾滋病毒健康调查总体健康子量表(差异=12.1，95%可信区间=2.0-22.2，p=0.02)外，身体耐力或与健康相关的生活质量(HRQOL)没有改善。尽管干预组的身体耐力水平维持在基线水平，而对照组的身体耐力水平有所下降，但两组之间的差异很小，并不显著。CD_4~+T淋巴细胞计数也无明显变化。对于HIV感染者来说，锻炼似乎是安全的。如果锻炼计划更长或更渐进，身体耐力和HRQOL可能会得到改善。需要进一步的研究来为患者建立高效抗逆转录病毒治疗的锻炼指南。
The authors conducted a randomized controlled trial to assess the impact of a 15-week (20 minutes three times per week) home-based aerobic exercise intervention versus usual care on the physical endurance, immune status, and self-reported health status of 99 HIV-infected adults. In the exercise group, there was no improvement in physical endurance or health-related quality of life (HRQOL), except in the Medical Outcomes Study-HIV Health Survey Overall Health subscale (difference = 12.1, 95% confidence interval = 2.0-22.2, p = .02). Although physical endurance levels were maintained at baseline levels in the intervention group and declined in the control group, differences between the groups were small and not significant. There were also no significant changes in CD4+ T-lymphocyte counts. Exercise appears to be safe in HIV-infected patients. Improvements in physical endurance and HRQOL might result if the exercise protocol is longer or progressive. Further research is needed to establish guidelines for exercise in patients on highly active antiretroviral therapy.