A single social defeat transiently suppresses the anti-viral immune response in mice
A single social defeat transiently suppresses the anti-viral immune response in mice
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DOI：
10.1016/s0165-5728(99)00005-3
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发表时间：
1999-03-01
影响因子：
3.3
通讯作者：
Koolhaas, JM
中科院分区：
文献类型：
--
作者：
de Groot, J;van Milligen, FJ;Koolhaas, JM
大多数关于应激对抗病毒免疫的影响的研究都是在应激源下进行的，应激源持续时间较长，与物种的性质关系不大。在这篇文章中，我们研究了一种更接近现实情况的应激源，即雄性小鼠的社会失败，对抗病毒免疫的影响。在接种伪狂犬病病毒(一种疱疹病毒)后3或6天进行一次社会失败。给药后第1天，淋巴结细胞数、病毒特异性IL-2和干扰素-γ的产生及淋巴细胞增殖均受到抑制，但随后这些指标迅速恢复到对照水平。我们的结论是，单一社会失败的压力会引起短暂的免疫抑制，如果涉及致病性或致命性病毒，这可能会产生后果。(C)1999 Elsevier Science B.V.保留所有权利。
Most of the studies dealing with effects of stress on anti-viral immunity have been carried out with stressors that are of long duration and that bear little relationship to the nature of the species. In this paper, we investigated the effect of a stressor mimicking real-life situations more closely, being social defeat of male mice, on anti-viral immunity. A single social defeat was applied at 3 or 6 days after inoculation with pseudorabies virus, a herpes virus. It appeared that lymph node cellularity, virus specific IL-2 and IFN-gamma production and lymphocyte proliferation were suppressed at 1 day after defeat, but these parameters restored to control values quickly thereafter. We conclude that the stress of a single social defeat evokes a transient immune suppression, which might have consequences if a pathogenic or lethal virus is involved. (C) 1999 Elsevier Science B.V. All rights reserved.