Risk of thyroid cancer after childhood exposure to ionizing radiation for tinea capitis
Risk of thyroid cancer after childhood exposure to ionizing radiation for tinea capitis
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DOI：
10.1210/jc.2006-0743
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发表时间：
2006-12-01
影响因子：
5.8
通讯作者：
Novikov, Ilya
中科院分区：
文献类型：
--
作者：
Sadetzki, Siegal;Chetrit, Angela;Novikov, Ilya
背景：已知甲状腺对电离辐射的致癌作用敏感，尤其是儿童。风险和潜伏期效应的潜在修饰剂的作用需要进一步研究。我们研究了低剂量的电离辐射（4.5-49.5 cGy）的影响，对发展甲状腺癌的风险后，长达54年的潜伏期后，儿童exposure.Methods：研究人群包括10,834个人照射对atrocapitis在20世纪50年代和两个匹配的非照射组（一般人群和兄弟姐妹）进行比较。癌症统计和生命状况数据来自国家登记处，更新至2002年12月。采用Poisson回归分析方法，计算每戈瑞的超额相对危险度（ERR/戈伊）和超额绝对危险度（RR/Gy），并进行生存分析。发生甲状腺癌的总ERR/戈伊和每戈瑞每104人-年的超额绝对风险分别达到20.2（95%置信区间11.8-32.3）和9.9（95%置信区间5.7-14.7）。风险与剂量呈正相关，与暴露年龄呈负相关。ERR/戈伊显着升高10-19年后曝光，峰值在20-30年，并显着下降（虽然仍然显着升高）40 yr后exposure.Conclusions：我们的研究结果同意在大多数辐射诱发甲状腺癌的研究中看到的风险修改模式，虽然每单位剂量的风险似乎更高。我们的数据显示，照射后40年，ERR急剧下降，但仍显着升高。犹太人群不同遗传易感性的假说值得进一步探讨。
Background: The thyroid gland is known to be sensitive to the carcinogenic effect of ionizing radiation, especially in children. The role of potential modifiers of the risk and latency period effects needs further investigation. We examined the effect of low doses of ionizing radiation (4.5-49.5 cGy) on the risk of developing thyroid cancer after long latent periods of up to 54 yr after childhood exposure.Methods: The study population included 10,834 individuals irradiated against tinea capitis in the 1950s and two matched nonirradiated groups (general population and siblings) for comparison. Cancer statistics and vital status data were obtained from national registries, updated to December 2002. Excess relative and absolute risks [excess relative risk per gray (ERR/Gy), excess absolute risk (EAR)] were estimated using Poisson regression for survival analysis.Results: Within the study period, 159 cases of thyroid cancer were diagnosed. Total ERR/Gy and excess absolute risk per gray per 104 person-years for developing thyroid cancer reached 20.2 (95% confidence interval 11.8-32.3) and 9.9 (95% confidence interval 5.7-14.7), respectively. The risk was positively associated with dose and negatively associated with age at exposure. ERR/Gy was significantly elevated 10-19 yr after exposure, peaking at 20-30 yr, and decreasing dramatically (although still significantly elevated) 40 yr after exposure.Conclusions: Our findings agree with patterns of risk modification seen in most studies of radiation-induced thyroid cancer, although risk per unit dose seems higher. Our data show that 40 yr after irradiation, ERR decreases dramatically, although remaining significantly elevated. The hypothesis of different genetic susceptibility of the Jewish population deserves further exploration.