ANTEROVENTRAL 3RD VENTRICLE SITE OF ACTION FOR ANGIOTENSIN INDUCED THIRST
ANTEROVENTRAL 3RD VENTRICLE SITE OF ACTION FOR ANGIOTENSIN INDUCED THIRST
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DOI：
10.1016/0091-3057(76)90216-1
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发表时间：
1976-01-01
影响因子：
3.6
通讯作者：
FISHER, AE
中科院分区：
文献类型：
--
作者：
BUGGY, J;FISHER, AE
在大鼠中研究了血管紧张素诱导口渴的中枢作用部位。穹窿下器官病变暂时取消饮酒引起的侧视前或侧脑室微量注射血管紧张素，但饮酒前腹侧第三脑室微量注射血管紧张素（或卡巴胆碱）不受影响。饮酒导致全身血管紧张素水平升高的作用减弱，但不能被穹窿下器官病变所消除。当通过在脑室的选定位置放置塞子来控制注射的血管紧张素通过CSF循环的扩散时，仅当颅内微量注射血管紧张素进入前腹侧第三脑室时才引起饮水。穹窿下器官不是血管紧张素的唯一致渴受体;相反，血管紧张素通过心室系统扩散到前腹侧第三脑室附近的受体，至少发挥其致渴效应的一部分。
The central site of action for angiotensin induced thirst was investigated in rats. Subfornical organ lesions temporarily abolished drinking induced by lateral preoptic or lateral ventricle microinjections of angiotensin, but drinking to anteroventral 3rd ventricle microinjections of angiotensin (or carbachol) was unaffected. Drinking to elevated systemic levels of angiotensin was attenuated but not abolished by subfornical organ lesions. When spread of injected angiotensin via CSF circulation was controlled by placing plugs at selected locations in the ventricles, drinking was elicited only when intracranial microinjections of angiotensin gained access to anteroventral 3rd ventricle. Subfornical organ is not the exclusive dipsogenic receptor for angiotensin; rather angiotensin exerts at least part of its dipsogenic effect by spread through the ventricular system to receptors in the vicinity of the anteroventral 3rd ventricle.