Relationship Between Thyroid Hormone Levels and the Pathology of Alzheimer's Disease in Euthyroid Subjects
Relationship Between Thyroid Hormone Levels and the Pathology of Alzheimer's Disease in Euthyroid Subjects
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DOI：
10.1089/thy.2019.0727
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发表时间：
2020-06-16
期刊：
影响因子：
6.6
通讯作者：
Kim, Hae Won
中科院分区：
文献类型：
--
作者：
Choi, Byung Wook;Kim, Shin;Kim, Hae Won
Background:Although several studies have reported an association between thyroid dysfunction and Alzheimer's disease (AD), the effect of mild thyroid dysfunction within the normal range of thyrotropin (TSH) on the development of AD remains unclear. The aim of this study was to evaluate the association between thyroid hormones and the pathology of AD in euthyroid subjects. Methods:Sixty-nine subjects with a TSH level between 0.5 and 4.5 mu IU/L who underwent(18)F-florbetaben positron emission tomography were included in this prospective cross-sectional study. The levels of serum free thyroxine (fT4) and TSH were quantified using radioimmunoassay. Neuropsychological tests were performed to assess cognitive function. Differences in cerebral amyloid-beta (A beta) burden were compared between high-normal TSH (TSH >= 2.5 mu IU/mL) and low-normal TSH (TSH
