Antimicrobial effect of platelet-rich plasma and platelet-rich fibrin.
Antimicrobial effect of platelet-rich plasma and platelet-rich fibrin.
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DOI：
10.4103/0970-9290.186231
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发表时间：
2016-05-01
期刊：
影响因子：
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通讯作者：
Warang, Ayushya D
中科院分区：
文献类型：
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作者：
Badade, Pallavi S;Mahale, Swapna A;Warang, Ayushya D
背景：血小板浓缩物已广泛用于各种医学领域，以促进软组织和硬组织再生。其使用背后的意义在于血小板α颗粒中丰富的生长因子（GF），可促进伤口愈合。除了释放一个池的GF激活后，血小板也有许多功能，表明他们的作用，在抗感染宿主defendance.AIM：本研究的目的是评估抗微生物活性的富血小板血浆（PRP）和富血小板纤维蛋白（PRF）对牙周病相关bacteries.SUBJECTS和方法：血液样本来自10名成年男性患者。使用离心获得PRP和PRF。用牙龈卟啉单胞菌和伴放线菌聚集杆菌培养法评价PRP和PRF的抗菌活性。结论：PRP是一种潜在的抗牙周致病菌的有效物质。这可能是一个有价值的属性辅助组织再生的增强。
CONTEXT: Platelet concentrates have been extensively used in a variety of medical fields to promote soft- and hard-tissue regeneration. The significance behind their use lies in the abundance of growth factors (GFs) in platelets alpha-granules that promote wound healing. Other than releasing a pool of GFs upon activation, platelets also have many features that indicate their role in the anti-infective host defense.AIM: The aim of this study is to evaluate the antimicrobial activities of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) against periodontal disease-associated bacteria.SUBJECTS AND METHODS: Blood samples were obtained from ten adult male patients. PRP and PRF were procured using centrifugation. The antimicrobial activity of PRP and PRF was evaluated by microbial culturing using bacterial strains of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans.RESULTS: P. gingivalis and A. actinomycetemcomitans were inhibited by PRP but not by PRF.CONCLUSIONS: PRP is a potentially useful substance in the fight against periodontal pathogens. This might represent a valuable property in adjunct to the enhancement of tissue regeneration.