The Y chromosome of Drosophila melanogaster exhibits chromosome-wide imprinting.
The Y chromosome of Drosophila melanogaster exhibits chromosome-wide imprinting.
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果蝇的 Y 染色体表现出全染色体印记。
DOI：
10.1093/genetics/162.3.1245
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发表时间：
2002
期刊：
影响因子：
3.3
通讯作者：
Golic,KentG
中科院分区：
文献类型：
--
作者：
Maggert,KeithA;Golic,KentG
基因组印记是染色体上几个特定区域的调节特性，导致母系和父系遗传等位基因的差异行为。我们调查了两个报告基因在23个独立的P-元件插入异染色质Y染色体上的活性ofDrosophilamelanogasterand发现，除了一个位置显示差异表达的一个或两个基因根据染色体的亲本来源。相反，插入常染色体异染色质中的基因通常不显示印记调节的表达。这些印记建立在插入到许多不同序列和位置的Y连锁转基因上。我们的结论是基因组印记影响基因表达是果蝇Y染色体的一般属性，并区分了Y从常染色体补体。
Genomic imprinting is well known as a regulatory property of a few specific chromosomal regions and leads to differential behavior of maternally and paternally inherited alleles. We surveyed the activity of two reporter genes in 23 independentP-element insertions on the heterochromaticYchromosome ofDrosophila melanogasterand found that all but one location showed differential expression of one or both genes according to the parental source of the chromosome. In contrast, genes inserted in autosomal heterochromatin generally did not show imprint-regulated expression. The imprints were established onY-linked transgenes inserted into many different sequences and locations. We conclude that genomic imprinting affecting gene expression is a general property of the DrosophilaYchromosome and distinguishes theYfrom the autosomal complement.